Synthesis of imprinted beads by aqueous suspension polymerisation for chiral recognition of antihistamines

Walsh, Rachel; Osmani, Qendresa; Hughes, Helen; Duggan, P F; McLoughlin, Peter

doi:10.1016/j.jchromb.2011.09.036

Cited by 23 publications

(14 citation statements)

References 21 publications

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“…For suspension polymerization, the traditional water medium, perfluorocarbon liquid and mineral oil can be used as the continuous phase, however, the method tends to produce a broad size range from micrometers to millimeters and displays poor recognition due to the disturbance of the dispersing medium, which is not suitable for solid phase extraction (SPE) applications. [59][60][61] Emulsion polymerization is an effective method to produce high yield, monodispersed MIP particles either oil-in-water (O/W) or water-in-oil (W/O), which suffers from the disturbance of remnants of surfactants. 62,63 Controlled diameter spherical MIPs have been directly prepared and modified in situ by using a multi-step swelling method, also called seed polymerization.…”

Section: Preparation Proceduresmentioning

confidence: 99%

Molecular imprinting: perspectives and applications

et al. 2016

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a Molecular imprinting technology (MIT), often described as a method of making a molecular lock to match a molecular key, is a technique for the creation of molecularly imprinted polymers (MIPs) with tailor-made binding sites complementary to the template molecules in shape, size and functional groups. Owing to their unique features of structure predictability, recognition specificity and application universality, MIPs have found a wide range of applications in various fields. Herein, we propose to comprehensively review the recent advances in molecular imprinting including versatile perspectives and applications, concerning novel preparation technologies and strategies of MIT, and highlight the applications of MIPs. The fundamentals of MIPs involving essential elements, preparation procedures and characterization methods are briefly outlined.Smart MIT for MIPs is especially highlighted including ingenious MIT (surface imprinting, nanoimprinting, etc.), special strategies of MIT (dummy imprinting, segment imprinting, etc.) and stimuli-responsive MIT (single/dual/ multi-responsive technology). By virtue of smart MIT, new formatted MIPs gain popularity for versatile applications, including sample pretreatment/chromatographic separation (solid phase extraction, monolithic column chromatography, etc.) and chemical/biological sensing (electrochemical sensing, fluorescence sensing, etc.). Finally, we propose the remaining challenges and future perspectives to accelerate the development of MIT, and to utilize it for further developing versatile MIPs with a wide range of applications (650 references).

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Section: Preparation Proceduresmentioning

confidence: 99%

Molecular imprinting: perspectives and applications

et al. 2016

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“…Ao se definir a molécula modelo e o monômero funcional, é necessário observar e estimar as possíveis interações intermoleculares que ocorrerão entre eles, a fim de que estas sejam favoráveis à retenção seletiva do analito. Relatos recentes apontam o ácido metacrílico (MAA) [52][53][54][55][56][57] e a 4-vinilpiridina (4-VP) [55,58] como os MFs mais utilizados. Os agentes de ligação cruzada (ALC) são os responsáveis pelo cará-ter tridimensional dos MIPs.…”

Section: Metodologias De Sínteseunclassified

“…Esta pode ocorrer por um processo termoquímico e/ou fotoquímico. O mais empregado é o azoisobutironitrila (AIBN) [52][53][54][55][56][57][58] . Com relação ao solvente utilizado, é importante lembrar que ele deve solubilizar os reagentes sem que haja reação entre eles.…”

Section: Metodologias De Sínteseunclassified

“…Os pequenos monólitos formados foram pulverizados e tamisados para utilização [56] . Para análise de anti-histamínicos em água, um procedimento similar foi adotado por Walsh et al, tendo como único diferencial o acréscimo de água no meio reacional [57] . A síntese por suspensão também pode ser realizada por intermédio de polímeros com granulometria conhecida, inicialmente colocados nas gotículas da suspensão.…”

Section: Metodologias De Sínteseunclassified

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Emprego de polímeros de impressão molecular em preparo de amostras para análise de compostos orgânicos: aplicações e tendências

Santos¹,

Abrão²,

Freitas³

et al. 2012

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ResumoOs polímeros de impressão molecular são materiais sintéticos dotados de sítios específicos de reconhecimento. Esses materiais são obtidos por reações de polimerização que fixam, estrategicamente, monômeros funcionais ao redor de uma molécula modelo de acordo com os grupos ligantes e com a estereoquímica de ambas as moléculas. Os MIPs têm sido amplamente empregados em procedimentos de preparo de amostras, como extração e microextração em fase sólida, extração sortiva em barra de agitação, extração com adsorvente magnético, microextração com sorvente empacotado, entre outras. Este artigo de revisão tem como objetivo apresentar o que há de mais recente no emprego de MIP para extração de compostos orgânicos, evidenciando as vantagens de cada aplicação, bem como as mais promissoras tendências que sustentam a evolução e o aperfeiçoamento de cada técnica. Palavras-chavePolímeros de impressão molecular; MIP; preparo de amostras.Molecularly imprinted polymers in sample preparation for organic compounds analysis: applications and trends AbstractMolecularly imprinted polymers are synthetic materials with molecular recognition ability. These materials are obtained by polymerization reactions that fix the functional monomers around the template molecule according with the binding groups and the stereochemistry of both molecules. The MIPs have been extensively used in several applications with emphasis for sample preparation procedures as solid phase extraction, solid phase microextraction, extraction by magnetic sorbents, microextraction by packed sorbent among others. So, the objective of this review is to present the novelty in MIP use for organic compounds extraction and point out the advantages of each application, as well as what is most promising in the evolution and improvement of each technique.

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“…MIP showed the highest recognition for chlropheniramine and slight recognition for its structurally related compounds. Preparation of spherical MIP is described by Walsh et al [14] with chlropheniramine and other antihistamine drugs and studied the physical properties of the polymers. Recent MIP was reviewed by Jesika et al [15] including the previous and current literature regarding the analytical tools employed for synthesized MIPs.…”

Section: Introductionmentioning

confidence: 99%

Synthesis, Characterization of Chlropheniramine maleate– Molecularly Imprinted Polymers and Their Application as Sensors for the Determination of the Drug in Some Pharmaceutical Preparations

Raad¹,

Alsamarrai²,

Al-Bayati³

2017

IHJPAS

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New chlropheniramine maleate (CPM) selective electrochemical membranes were prepared by using chlropheniramine maleate -molecularly imprinted polymers. MIP was prepared by bulk polymerization using 2-hydroxyethyl methacrylate (2-HEMA) as monomer, ethylene glycol dimethacrylate (EGDMA) as a cross-linker and a benzoyl peroxide (BPO) as an initiator at 60 0 C. Three CPM-MIP electrodes were constructed by using tri-tolyl Phosphate (ToCP), tris (2-ethyl hexyl) Phosphate (TEHP) and tributyl Phosphate (TBP) as plasticizers in PVC matrix.Electrode parameters including slopes, working concentrations ph. The interference effect in the presence of (Na + , Mg +2 , Al +3 , Glycine, Alanine, Arginine and Phenylalanine) was studied using the separated and mixed methods to determine the selectivity coefficient determination. NIP prepared by using the same composition of MIP molecularly imprinted polymer electrodes except the template (CPM). The slopes of CMP-MIP are 21.00, 21.50 and 19.08 mV/ decade, linearity range for the electrodes around. (10 -5 -10 -1 ) M, the stable at a pH range from 4.0 to 8.5 and lifetime ranged from 30 to 10 days. The suggested electrodes were successfully applied for the determine of CPM in some pharmaceutical preparations, which were given acceptable accuracy.

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Synthesis of imprinted beads by aqueous suspension polymerisation for chiral recognition of antihistamines

Cited by 23 publications

References 21 publications

Molecular imprinting: perspectives and applications

Molecular imprinting: perspectives and applications

Emprego de polímeros de impressão molecular em preparo de amostras para análise de compostos orgânicos: aplicações e tendências

Synthesis, Characterization of Chlropheniramine maleate– Molecularly Imprinted Polymers and Their Application as Sensors for the Determination of the Drug in Some Pharmaceutical Preparations

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