“…The isocyanide based multicomponent reactions (I-MCRs), especially Ugi four-component reactions, have played a vital role in organic and medicinal chemistry due to their efficient construction of small-molecule libraries in a mild one-pot fashion. , The Ugi-azide reactions have also provided a powerful method for synthesis of 1,5-disubstituted tetrazoles, as the carboxylic acid component is changed to hydrazoic acid (produced in situ from NaN 3 or TMS-N 3 ). − In recent years, the sequence of Ugi reaction and other organic reactions has been successfully applied in the synthesis of many heterocyclic compounds. − For example, the tandem post-Ugi cyclization and Gold(I)-catalyzed regioselective annulation were utilized in the preparation of densely functionalized pyrrolo[1,2- a ]pyrazine-3,6(2 H ,4 H )-diones in good to excellent yields . Diverse benzazepinoindoles were assembled in a step-economical, chemo- and regioselective fashion by an Ugi/gold-catalyzed alkyne hydroarylation/Michael addition sequence .…”