Synthesis ofN-Methyl Secondary Amines

Design, synthesis and evaluation of chromone-2-carboxamido-alkylbenzylamines as multifunctional agents for the treatment of Alzheimer’s disease

“…The trend for AChE inhibitiory activities was 7-H > 7-OCH 3 > 7-N(CH 3 ) 2 > 7-OH. The screening data exhibited that the structure of terminal groups NR 1 R 2 of side chain effected the inhibitory activities, generally, the potency to inhibit AChE were in [1,4] (20)(21)(22)(23) showed low inhibitory activity and none selectivity toward AChE and BuChE, indicating that the introduction of the O-alkylamines increased the ChEs inhibitory capacity and improved the selectivity for AChE over BuChE, which is identical to our design strategy. Overall, the results suggested that N- (2-methoxybenzyl)ethylamine and N-(2-dimethylaminobenzyl)ethylamine might be the optimal substitution patterns for AChE inhibition.…”

“…It was synthesized from 5-hydroxy-7-methoxy-4-oxo-4H-chromene-2-carboxylic acid (20) and It was synthesized from 5-hydroxy-7-methoxy-4-oxo-4H-chromene-2-carboxylic acid (20) and …”

Derivatization of carbonyl compounds with 2,4-dinitrophenylhydrazine and their subsequent determination by high-performance liquid chromatography

“…In order to resolve the isometric problem, it is necessary to transform the C N double bond to a C-N single bond through use of a reducing agent. Various kinds of reducing agents, such as sodium cyanohydridoborate (NaBH 3 CN) [59,60], sodium triacetoxyborohydride (Na(OAc) 3 BH) [61][62][63][64][65], pyridine-borane (pyr-BH 3 ) [66][67][68], titanium(IV) isopropoxide/sodium borohydride (Ti(Oi-Pr) 4 /NaBH 4 ) [69][70][71][72], borohydride exchange resin [73], zinc borohydride/silica gel (Zn(BH 4 ) 2 /SiO 2 ) [74], and phenylsilane/dibutyltin dichloride (PhSiH 4 /Bu 2 SnCl 2 ) [75] have been developed for this conversion. The choice of the reducing agent is very critical to the success of the reaction, since the reducing agent must reduce imines selectively.…”

Synthesis of Bishomobenzoctamine 2-(9,10-Dihydro-9,10-Propanoanthracen-9-yl)-N-Methylethanamine

“…The crude product was purified by flash column chromatography (hexane-dichloromethene 1:1 to give 6 (4. 6 9-(Prop-2-en-1-yl)-9,10-dihydro-9,10-propanoanthracen-12-one (6): (3.16 g, 48.32 mmol) powdered zinc, (1.35 g, 13.64 mmol) CuCl and a small amount of absol. dioxane was placed into a flame-dried flask filled.…”