Synthesis of hydroxyethylcellulose phthalate-modified silver nanoparticles and their multifunctional applications as an efficient antibacterial, photocatalytic and mercury-selective sensing agent

Siddique, Abu Bakar; Amr, Dina; Abbas, Azhar; Zohra, Lubna; Irfan, Muhammad I.; Alhoshani, Ali; Ashraf, Saima; Amin, Hatem M.A.

doi:10.1016/j.ijbiomac.2023.128009

Cited by 30 publications

(6 citation statements)

References 45 publications

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“…By utilizing the simple charge interaction between CPP and anti-VEGF drugs to non-covalently bind them, we successfully synthesized two eye drop formulations, 5-FCR and 5-FCC, and characterized them through various methods. 34,35 This method not only enhanced the ability of drugs to traverse tissue barriers and enter cells but also ensured the biological effectiveness of the drugs would not be compromised by the permanent attachment of CPP, while overcoming the complications and adverse reactions that still rely on injection platform administration in previous studies. [36][37][38] The potential toxicity of the carrier-drug complexes is a focal point of our investigation.…”

Section: Discussionmentioning

confidence: 99%

Topical Application of Cell-Penetrating Peptide Modified Anti-VEGF Drug Alleviated Choroidal Neovascularization in Mice

Hu,

Cai,

et al. 2024

IJN

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Background Age-related macular degeneration (AMD) stands as the foremost cause of irreversible central vision impairment, marked by choroidal neovascularization (CNV). The prevailing clinical approach to AMD treatment relies on intravitreal injections of anti-vascular endothelial growth factor (VEGF) drugs. However, this method is encumbered by diverse complications, prompting exploration of non-invasive alternatives such as ocular administration via eye drops for anti-VEGF therapy. Methods Two complexes, 5-FITC-CPP-Ranibizumab (5-FCR) and 5-FITC-CPP-Conbercept (5-FCC), were synthesized by incorporating the anti-VEGF drugs Ranibizumab (RBZ) or Conbercept (CBC) with cell-penetrating peptide (CPP). Circular dichroism spectrum (CD) facilitated complexes characterization. Eye drops was utilized to address laser-induced CNV in mice. Fluorescein fundus angiography (FFA) observe the CNV lesion, while FITC-dextran and IB4 dual fluorescent staining, along with hematoxylin-eosin (HE) staining, assessed in lesion size. Tissue immunofluorescence examined CD31 and VEGF expression in choroidal/retinal pigment epithelial (RPE) tissues. Biocompatibility and biosafety of 5-FCR and 5-FCC was evaluated through histological examination of various organs or cell experiments. Results Both 5-FCR and 5-FCC exhibited favorable biocompatibility and safety profiles. VEGF-induced migration of Human umbilical vein endothelial cells (HUVECs) significantly decreased post-5-FCR/5-FCC treatment. Additionally, both complexes suppressed VEGF-induced tube formation in HUVECs. FFA results revealed a significant improvement in retinal exudation in mice. Histological examination unveiled the lesion areas in the 5-FCR and 5-FCC groups showed a significant reduction compared to the control group. Similar outcomes were observed in histological sections of the RPE-choroid-sclera flat mounts. Conclusion In this study, utilizing the properties of CPP and two anti-VEGF drugs, we successfully synthesized two complexes, 5-FCR and 5-FCC, through a straightforward approach. Effectively delivering the anti-VEGF drugs to the target area in a non-invasive manner, suppressing the progression of laser-induced CNV. This offers a novel approach for the treatment of wet AMD.

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Section: Discussionmentioning

confidence: 99%

Topical Application of Cell-Penetrating Peptide Modified Anti-VEGF Drug Alleviated Choroidal Neovascularization in Mice

Hu,

Cai,

et al. 2024

IJN

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“…Applications of nanotechnology have practically impacted all aspects of modern life. For a couple of decades, the synthesis of nanostructures has attracted significant attention due to their potential uses in various fields, including optoelectronics, , catalysis, , sensing, − water purification, − nanomedicine, − efficient antimicrobial agents, , etc. Silver nanoparticles (Ag-NPs) have received more attention than other noble metal nanostructures as efficient antimicrobial agents against different Gram-positive and Gram-negative bacterial strains.…”

Section: Introductionmentioning

confidence: 99%

Investigating the Antibacterial and Anti-inflammatory Potential of Polyol-Synthesized Silver Nanoparticles

Ahmad,

Khan,

Hayat

et al. 2024

ACS Omega

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Silver nanoparticles (Ag-NPs) were synthesized by using the polyol method. The structural and morphological characteristics of Ag-NPs were studied by using X-ray diffraction (XRD) and field-emission scanning electron microscopy (FE-SEM). The XRD analysis revealed the formation of single-phase polycrystalline Ag-NPs with an average crystallite size and lattice constant of ∼23 nm and 4.07 Å, respectively, while the FE-SEM shows the formation of a uniform and spherical morphology. Energy-dispersive X-ray spectroscopy confirmed the formation of single-phase Ag-NPs, and no extra elements were detected. A strong absorption peak at ∼427 nm was observed in the UV− vis spectrum, which reflects the surface plasmon resonance (SPR) behavior characteristic of Ag-NPs with a spherical morphology. Fourier-transform infrared (FTIR) spectra also supported the XRD and EDX results with regard to the purity of the prepared Ag-NPs. Anti-inflammatory activity was tested using HRBCs membrane stabilization and heatinduced hemolysis assays. The antibacterial activity of Ag-NPs was evaluated against four different types of pathogenic bacteria by using the disc diffusion method (DDM). The Gram-negative bacterial strains used in this study are Escherichia coli (E. coli), Klebsiella, Shigella, and Salmonella. The analysis suggested that the antibacterial activities of Ag-NPs have an influential role in inhibiting the growth of the tested Gram-negative bacteria, and thus Ag-NPs can find a potential application in the pharmaceutical industry.

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“…Recovery is an extremely important operation in the case of metals used in key industrial sectors but not very widespread, such as, for example, highly scarce rhenium or precious metals (e.g., gold and platinum) [16,17]. Additionally, some of the modern adsorbents developed can have multi-functional applications; for example, they can serve as effective antibacterial materials and metal-selective sensing agents [18]. The group of well-known and frequently used adsorbents enabling efficient adsorption of various water pollutants includes, among others, activated carbon, zeolite, clay ore, and alumina.…”

Section: Introductionmentioning

confidence: 99%

The Application of Chitosan-Based Adsorbents for the Removal of Hazardous Pollutants from Aqueous Solutions—A Review

Kaczorowska,

Bożejewicz

2024

Sustainability

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The development of simple, effective, economical, and environmentally friendly methods for removing hazardous substances of anthropogenic origin from aquatic systems is currently one of the greatest challenges, among others, due to the variety of pollutants and the transformations they may undergo in the environment. In recent years, there has been an increased interest in adsorption methods based on the use of natural polymers, including non-toxic chitosan (CS), which is characterized by good coating properties, biocompatibility, and biodegradability. This review concerns the latest developments (since 2019) in the application of novel chitosan-based materials for the removal of hazardous substances (e.g., metal and metalloid ions, synthetic dyes, pharmaceuticals) from aqueous solutions, with particular emphasis on their most important advantages and limitations, as well as their potential impact on sustainability.

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Synthesis of hydroxyethylcellulose phthalate-modified silver nanoparticles and their multifunctional applications as an efficient antibacterial, photocatalytic and mercury-selective sensing agent

Cited by 30 publications

References 45 publications

Topical Application of Cell-Penetrating Peptide Modified Anti-VEGF Drug Alleviated Choroidal Neovascularization in Mice

Topical Application of Cell-Penetrating Peptide Modified Anti-VEGF Drug Alleviated Choroidal Neovascularization in Mice

Investigating the Antibacterial and Anti-inflammatory Potential of Polyol-Synthesized Silver Nanoparticles

The Application of Chitosan-Based Adsorbents for the Removal of Hazardous Pollutants from Aqueous Solutions—A Review

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