Synthesis of Hydroxamic Ligands with Transition Metal Complexes, their Biological Activities and Characterization Through Spectroscopic Techniques

Abstract

New metal complexes including Ni (Ⅱ), Co (Ⅱ), Cu (Ⅱ), Fe (Ⅲ), Cr (Ⅲ), Cd (Ⅱ) and Zn ( Ⅱ ) have been synthesized from parent ligand N-methyl mnitrobenzohydroxamic acid. The condensation ratio is 2:1 of the ligand and metal salt (MX) in methanol. The ligand N-methyl m-nitrobenzohydroxamic has been prepared by the interaction of N-methylhydroxylamine hydrochloride with m-nitrobenzoyl chloride. The coordination modes and bonding of the ligands along with its metal complexes have been identified by FT-IR, 1H-NMR and UV-Vis spectroscopic techniques. It has been enumerated by spectroscopic techniques that the complex is formed via O, O-coordination to metal through the oxygen of carbonyl group and deprotonated hydroxyl group. The antibacterial and antifungal activities of the ligand as well as its complexes have been estimated against two gram negative strains such as Escherichia coli and Salmonella typhi, one gram positive strain Escherichia coli and one fungal strain yeast. In addition to this the cytotoxicity and antitumor activities have been evaluated resistant to Brine shrimps eggs and Hela cell line respectively.

A New Green Approach of CFIA Technique for Direct Assay with a High Throughput of Sulfamethoxazole Drugs Using Condensation Reaction with NQS Agent

“…Several methods have been described for SMZ drug estimation like flow injection analysis 4 . selective electroed 5 , spectrophotometric method [6][7][8] , HPLC [9][10][11] , and fluorometry 13 in this manuscript, an accurate, sensitive, and simple of semiautomated flow injection analysis CFIA/MZ technique [14][15][16][17][18] were used to examine the quantitate…”

Determination of Sulfamethoxazole in Pure and Pharmaceutical Samples by Using Direct Method for Calibration Curve of Normal Spectrum of UV-Spectrophotometry

“…Researchers have developed various analytical methods to determine sulfamethoxazole in biological samples and formulations, such as ion selective electrodes [2][3][4], chromatographic [5,6], and HPLC (High Performance Liquid Chromatography) [7][8][9] methods. UV spectrophotometer can be used to investigate the interaction of matter with light radiation in visible (400-800) range and the ultra-violet (200-400) [10,11]. UV radiation has enough energy to excite valence electrons in molecules or many atoms from their terrestrial state to higher energy levels.…”