Synthesis of hydrogenated 2,7-dimethylpyrrolo[3,4-b]indoles – analogs of dimebon

Syntheses and radioligand activities of dimebon analogs

“…However, the spectrum of the (E)-isomer XII exhibited analogous resonances at 6.65 and 7.39 ppm with a much greater SSCC (14.8 Hz). Such values of the SSCC are characteristic of the discussed cis-and trans-isomers [14,18].…”

Cross‐Cycloaddition of Two Different Isocyanides: Chemoselective Heterodimerization and [3+2]‐Cyclization of 1,4‐Diazabutatriene

“…[14] Additionally,t hey are stable analogues of indole-2,3-quinodimethanesu sed for preparation of carbazoles,c arbolines,a nd related heterocyclic systems,t hrough cycloaddition reactions. [15,16] Moreover,t he pyrrolo [3,4-b]indole derivatives show ab road spectrum of pharmacological activity. [13] Although many methods for the construction of pyrrolo [3,4-b]indoles have been developed, ap reformed indole precursor is generally required.…”

ChemInform Abstract: PyBidine/Copper Catalyst: Asymmetric exo′‐Selective [3 + 2] Cycloaddition Using Imino Ester and Electrophilic Indole.

“…[6a] An exo'-selective enantioselective cyclization also has been achieved using a chiral IAP/Ni catalyst. [9,10] This strategy allows synthesis of pyrrolo [3,4-b]indole derivatives, [11,12] having a quaternary carbon center, which are structural isomers of cyclotryptamines. [9,10] This strategy allows synthesis of pyrrolo [3,4-b]indole derivatives, [11,12] having a quaternary carbon center, which are structural isomers of cyclotryptamines.…”