Synthesis of hydrazones containing sterically hindered phenol groups and tetrathiacalix[4]arene fragment

Synthesis, in-vitro antioxidant activity and in-silico prediction of drug-likeness properties of a novel compound: 4-(3,5-Di-tert-butyl- 4-hydroxybenzylidene)-3-methylisoxazol-5(4H)-one

“…Generally, it can be prepared from p-cresol by dibutylation or from 2,6-di-tert-butylphenol by aminomethylation or hydroxymethylation followed by hydrogenolysis. Various synthetic derivatives containing BHT or 2,6-di-tert-butylphenol moiety such as chalcones (Cabral et al, 2017;Won et al, 2005), hydrazones (Cuadro et al, 1998;Duarte et al 2007;Podyachev et al, 2012), styryl heterocycles (Flynn et al, 1991;Lazer et al, 1989;Kelarev et al, 2003;Madhavi et al, 2010;Mullican et al, 1993), benzylidene compounds (Clemens et al, 1991;Hori et al, 2002;Ikuta et al, 1987;Inagaki et al, 2000;Katsumi et al, 1986;Phillips et al, 1992;Unangst et al, 1994;Wong et al, 1992), and other heterocyclic systems (Gowdra et al, 2014;Isomura et al, 1983a;1983b;1984;Jeong et al, 2004;Unangst et al, 1992;Ziakas et al, 2006) were reported to have anti-inflammatory activity with dual inhibition of 5-lipoxygenase and cyclooxygenase enzymes as well as low ulcerogenic liability. Several of these compounds were also reported to have anti-obesity, anti-tumor, and antioxidant activities.…”