Synthesis of highly monodisperse superparamagnetic iron oxide core@mesoporous silica shell particles with independently tunable size, and porosity

Fiedler, R; Beitzinger, Bastian; Walther, Paul; Lindén, Mika

doi:10.1016/j.micromeso.2022.112027

Cited by 5 publications

(5 citation statements)

References 51 publications

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“…The silica shell on the starting particles had virtually completely degraded after 2 h of incubation. This is not surprising, as the shell is highly porous and has large mesopores, as previously also evidenced by TEM tomography . Furthermore, the particles have not been calcined, which means that the degree of silica condensation is low.…”

Section: Resultssupporting

confidence: 62%

“…This is not surprising, as the shell is highly porous and has large mesopores, as previously also evidenced by TEM tomography. 17 Furthermore, the particles have not been calcined, which means that the degree of silica condensation is low. For the particles post-treated with TEOS, a clearly slower shell degradation was observed, and the degradation kinetics followed the order of the silica shell density/surface area.…”

Section: ■ Results and Discussionmentioning

confidence: 99%

“…Highly monodisperse SPION@MSN particles having a mean particle diameter of 196 nm were synthesized according to our recently described method. 17 Briefly, aggregates of superparamagnetic iron oxide crystallites (aggregate diameter = 90 nm, primary particle diameter = 8 nm) were coated with a highly porous shell of mesoporous silica having a dendritic mesopore structure; i.e., the mesopore size increases toward the rim of the particles. The mean mesopore diameter of the silica shell was 7 nm, and the specific pore volume was 1.16 mL g −1 , excluding the contribution from the interparticulate porosity.…”

Section: ■ Results and Discussionmentioning

confidence: 99%

“…For the synthesis of the mesoporous silica shell onto the PEI-functionalized SPIONs, a modified version of the biphasic stratification approach according to Shen et al was applied, and that has been described in detail in ref . In brief, triethanolamine (0.18 g, 1.21 mmol), ultrapure water (48.5 mL), and cetyltrimethylammonium chloride solution (25 wt %, 1.5 mL, 1.13 mmol) were added to a 100 mL round-bottomed flask.…”

Section: Methodsmentioning

confidence: 99%

“…The present study is aimed at addressing both of these points. We have recently described the synthesis of highly monodisperse SPION@MSN nanoparticles with tunable particle diameters . Such particles are interesting for theranostic applications, as they can serve as a drug delivery system, as magnetic resonance imaging (MRI) contrast agents, − and also offer the possibility for therapeutic hyperthermia. − In this study, we describe a method by which the density of the mesoporous silica shell and therefore also its degradation rate can be rationally tuned.…”

Section: Introductionmentioning

confidence: 99%

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Superparamagnetic Core–Mesoporous Silica Shell Nanoparticles with Tunable Extra- and Intracellular Dissolution Rates

Fiedler,

Sivakumaran,

Mallén

et al. 2024

Chem. Mater.

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Mesoporous silica nanoparticles have repeatedly been shown to be a promising drug carrier because of their high porosity, biocompatibility, and inherent degradability. The kinetics of degradation is an extremely important parameter, as both the clearance time in vivo and, in many cases, the drug delivery kinetics are closely linked to the dissolution rate. Thus, a synthetic means to control the dissolution rates is an important part of nanoparticle optimization for a given application. Another important parameter influencing the fate of the nanoparticles in a biological system is their size. Optimally, it should therefore be possible to independently tune the dissolution rate without simultaneously changing the particle size. Here, we present means to achieve this by looking at both intracellular and extracellular degradation, using mesoporous silica shell-SPION core nanoparticles, where the porosity of the shell can postsynthetically be varied without changing the original size of the particles in combination with the macrophage cell line J774.A1. Furthermore, it is also shown that the kinetics of intracellular silica dissolution is much slower than that of extracellular dissolution. However, the trends in terms of dissolution kinetics for the different particles also hold for intracellular dissolution. Furthermore, our results also indicate that the intracellular dissolution kinetics are related to the nanoparticle concentration within vesicular compartments.

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Section: Resultssupporting

confidence: 62%

Section: ■ Results and Discussionmentioning

confidence: 99%

Section: ■ Results and Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%