Synthesis of Highly Flexible Difluorinated Cyclopropanoid Nucleoside Analogues.

Abstract

Synthesis of Highly Flexible Difluorinated Cyclopropanoid Nucleoside Analogues. -The incorporation of fluorine substituents, cf. title compounds of type (I), may be of advantage for an improved biological activity, for higher bioavailability as well as for causing a retarded metabolism. -(CSUK, R.; EVERSMANN, L.; Z. Naturforsch., B: Chem. Sci. 59 (2004) 1, 77-94; Inst. Org. Chem., Martin-Luther-Univ. Halle-Wittenberg, D-06120 Halle/S., Germany; Eng.) -C. Oppel 22-215