Abstract:Computational modelling was used to identify scaffolds with the potential to disrupt the interaction between HIV-1 integrase and lens epitheliumderived growth factor (HIV-1-IN-LEDGF/p75). Virtual screening of commercial library collections led to the identification of N-(4-chlorophenyl)-7,7-dimethyl-2,5dioxo-1,2,5,6,7,8-hexahydroquinoline-3-carboxamide as a promising candidate.The synthesis of this compound and its derivatives involved the reaction of the corresponding carboxylic acid derivatives with aniline … Show more
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