Synthesis of Hexadecanolide

Harding, Maurice J. C.; Whalen, David M.

doi:10.1021/i360056a004

Cited by 15 publications

(17 citation statements)

References 10 publications

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“…5,21 Traditionally, tetraoxanes have been used in the industry for the production of macrocyclic hydrocarbons and lactones. 22,23 These compounds can initiate polymerization of olefins and their utility as high temperature initiators is also under investigation. 24 Vennerstrom et al exploited medicinal potential of this class of compounds and have shown that some of the compounds are equally active as artemisinin.…”

Section: Introductionmentioning

confidence: 99%

Tetraoxanes: Synthetic and Medicinal Chemistry Perspective

Kumar¹,

Savan²,

Rawat

2010

Medicinal Research Reviews

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The discovery of artemisinin from Chinese medicinal plant, Artemisia annua in 1971, opened a new era in the malarial chemotherapy. This discovery was the beginning of exploring peroxides as potential replacements for the traditional antimalarial drugs such as chloroquine and mefloquine. The structurally simple class of peroxides that emerged from these studies was the 1,2,4,5-tetraoxanes. This study describes the current status of tetraoxane-based antimalarials that show significant promises because of their artemisinin-like activity. Literature from 1999 has been critically reviewed and an attempt has been made to discuss various synthetic methods and structure-activity relationship study among the series of tetraoxane-based compounds. © 2010 Wiley Periodicals, Inc. Med Res Rev.

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Section: Introductionmentioning

confidence: 99%

Tetraoxanes: Synthetic and Medicinal Chemistry Perspective

Kumar¹,

Savan²,

Rawat

2010

Medicinal Research Reviews

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“…Monitoring of AGE maturation in vitro is better accomplished by following incorporation of 14C-[ UL]-glucose and spectroscopic techniques than by monitoring of molecular weight changes. For monitoring more precise modifications to protein tertiary structure, near UV CD spectra of modified y-crystallins has shown that glucose adducts had native-like secondary structure and non-native tertiary structure, with an altered environment for some of the modified y-crystallin aromatic residues (35)(36)(37).…”

Section: Discussionmentioning

confidence: 99%

Monitoring the progress of non‐enzymatic glycation in vitro

Shaw

Crabbe

1994

International Journal of Peptide and Protein Research

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The progress of in vitro non‐enzymatic glycation of bovine serum albumin was followed by using 14C‐glucose and a nitroblue tetrazolium assay, absorption and fluorescence spectroscopy, SDS gel electrophoresis and protease digestion. The number of adducts detectable using both 14C‐tracers and a fructosamine assay remained low at physiological glucose concentrations, fewer than five adducts being detectable. When glucose concentrations > 1.0 M were used the number of adducts was found to greatly exceed the number of lysyl residues available in BSA, indicative of cross‐linking between Maillard products. Incubation of BSA with glucose concentrations of up to 160 mM for one month produced no observable increase in molecular weight by SDS gel electrophoresis, showing that at physiological glucose concentrations, increases in molecular weight were minimal for short incubation periods, any marked changes (indicated by non‐penetration of the 7.5% SDS gel) requiring nine months incubation with ≥ 20 mM glucose. Increases in absorption were proportional to both the glucose concentration and the incubation time. Several absorption peaks, at 370, 488 and 554 nm, were consistent in appearance throughout the course of each incubation. Fluorescence spectroscopy of the modified proteins showed a disappearance of the fluorescence associated with peptide bonds and aromatic residues and the appearance of a broad peak at longer wavelengths due to the wide range of absorptive/fluorescent wavelengths of the developing Maillard products. Protease digestion gave similar patterns with non‐glycated and glycated protein, suggesting that glycation did not block digestion sites, and that partial digestion did not cause significant further exposure of susceptible sites. Our results show that while glycation ultimately results in protein conformational changes and the formation of large molecular weight species, these occur at a relatively late stage in the maturation of protein Maillard products, after ≥ nine months of incubation with glucose concentrations of ≥ 20 mM. Monitoring of AGE maturation in itro is better accomplished by following incorporation of 14C‐[UL]‐glucose and spectroscopic techniques than by monitoring of molecular weight changes. © Munksgaard 1994.

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“…Sahu et al (1998) and Salim & Gould (2000) made some predictions for future astrometric microlensing events. Harding et al (2018) estimated the astrometric microlensing rate for known stellar remnants, and McGill et al (2018) used the GAIA-TGAS catalog (Lindegren et al 2016) to make predictions for astrometric microlensing events. Furthermore, Bramich et al (2018) and Mustill et al (2018) made some predictions for microlensing events in the next ten and twenty years, respectively, based on the GAIA-DR2 catalog.…”

Section: Introductionmentioning

confidence: 99%

Toward the Measurement of the Mass of Isolated Neutron Stars: Prediction of Future Astrometric Microlensing Events by Pulsars

Ofek

2018

ApJ

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The mass of single neutron stars (NSs) can be measured using astrometric microlensing events. In such events, the center-of-light motion of a star lensed by a NS will deviate from the expected non-lensed motion and this deviation can be used to measure the mass of the NS. I search for future conjunctions between pulsars, with measured proper motion, and stars in the GAIA-DR2 catalog. I identified one candidate event of a star that will possibly be lensed by a pulsar during the next ten years in which the expected light deflection of the background star will deviate from the non-lensed motion by more than 50 µas. Given the position and proper motion of PSR J0846 − 3533, it will possibly pass ∼ 0.2 ′′ from a 19.0 G magnitude background star in 2022.9. Further assuming a 1.4 M ⊙ NS, the expected maximum deviation of the background star images from the uniform-rate plus parallax motion will be 91 µas. This pulsar position has a relatively large uncertainty and therefore additional observations are required in order to verify this event. I briefly discuss the opposite case, in which a pulsar is being lensed by a star. Such events can be used to measure the stellar mass via pulsar timing measurements. I do not find good candidates for such events with predicted variations in the pulsar period derivative (Ṗ ), divided by 1 s, exceeding 10 −20 s −1 . Since only about 10% of the known pulsars have measured proper motions, there is potential for an increase in the number of predicted pulsar lensing events.

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Synthesis of Hexadecanolide

Cited by 15 publications

References 10 publications

Tetraoxanes: Synthetic and Medicinal Chemistry Perspective

Tetraoxanes: Synthetic and Medicinal Chemistry Perspective

Monitoring the progress of non‐enzymatic glycation in vitro

Toward the Measurement of the Mass of Isolated Neutron Stars: Prediction of Future Astrometric Microlensing Events by Pulsars

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