Synthesis of Heterocyclic Scaffolds via Prins, Oxonium-Ene and Related Cyclization Reactions

Abstract

A variety of oxygen, nitrogen and sulfur heterocyclic compounds are synthesized via one-pot multicomponent, Prins–, aza–Prins–, thia–Prins–, oxonium–ene–, iminium–ene–, and thionium–ene–cyclization reactions. The reactions proceeds with high diastereo– and region–selectivity. Importantly, C–C, C–N, C–O and C–S bonds are formed in a single step. These procedures are extended for the synthesis of biologically active molecules and natural products.