Synthesis of heterocyclic compounds on the basis of cyclohexane-1,3-diones (review)

New Protocol for the Synthesis of 2-Alkanoyl- and 2-Aryloyl-5,5-dimethylcyclohexane-1,3-diones by the Reaction of Dimedone with Various Aldehydes and Cyanogen Bromide in the Presence of Triethylamine

“…15,16 For example, 2-formylcyclohexane-1,3-diones have been reported through heterocyclic synthesis. 18 Some β-triketones such as 3,6-β-dihydroxy-2-(13phenyltridecanoyl)-2-cyclohexen-1-one has been obtained from the natural source of Virola oleifera, 19 and the natural products 2-oleoylcyclohexane-1,3-dione and 4-hydroxy-2oleoylcyclohexane-1,3-dione have been extracted from the larval mandibular glands of Anagasta kuehniella. 20 Many kinds of β-triketones have been synthesized in the laboratory through different strategies including 1,3-dipolar cycloaddition of nitrile oxide to cyclohexenone, followed by the hydrogenation and aqueous hydrolysis, which afforded 2-acylcyclohexane-1,3-diones, 21 and from acid anhydrides (succinic and glutaric anhydrides) and isopropenyl acetate.…”