Synthesis of heterocycles via ligand-free palladium catalyzed reductive Heck cyclization

Recent Development in Palladium-Mediated Synthesis of Oxygen Heterocycles

“…14 In an investigation, Liu et al reported the use of aryl bromide 1 for the synthesis of 2,3-dihydrobenzofurans 2 under ligand free Pd(OAc) 2 -catalyzed reductive Heck 15 cyclization (Scheme 1). 16 However, an excellent improvement in the yield of 2 (87%)…”

Total synthesis of (±) commiphoranes C–D and their epimers

“…However, the reaction did not proceed under NaOAc/Et 4 NCl·H 2 O conditions (Table 1, entry 1). When a reducing agent, for example, HCO 2 Na, 10 was added to the above reaction, we successfully obtained benzofuran (±) 11 at a 60% yield (Table 1, entry 2). However, under these conditions, we observed that the starting materials were not completely reacted.…”

Regioselective and Stereoselective Synthesis of Pyridine‐Fused Benzoxepine Derivatives by Intramolecular Reductive Heck Cyclization[1]

“…However, the synthesis of benzoxepine derivatives via reductive Heck cyclization is not common. Recently, some Pd(0)‐catalyzed reductive cyclizations have been applied for the synthesis of natural and un‐natural products . Van der Eycken et al .…”