Synthesis of Heterocycles from Thioamides

A decade's overview of 2‐aminothiophenes and their fused analogs as promising anticancer agents

“…[24] Base-catalyzed cyclization of thioamides also has been reported as a method that yields 2-N,N-dialkylaminothiophenes (Scheme 3). [25] Other methods utilized isothiocyanates to obtain unique 2-aminothiophene derivatives as 2-phenylaminothiophenes and 2-amino-4-oxothiophene-3-carboxylic esters (Scheme 4). [20] Derivatives are obtained through different synthetic pathways.…”