Synthesis of heterochain polymers using chemically activated monomers (“Activated polycondensation”). Review

Katsarava, Ramaz

doi:10.1016/0032-3950(89)90001-4

Cited by 2 publications

(3 citation statements)

References 66 publications

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“…On the basis of polymeric natural aminoacids of biodegradable AABB type with high bio-compatibility skills, synthesis and system-atic study of which are carried out in Georgia (Katsarava, 1989;Kharadze, 1998), are received prospective compounds in the form of matrixes of medicinal preparations. Bio-compatibility capacity and low immunogenic properties of these polymers are conditioned by monomers' nature and structure of polymeric chains.…”

Section: Characterization and Properties Of Polyesteramides Containin...mentioning

confidence: 99%

Characterization and Properties of Polyesteramides

LOLADZE,

NEPARIDZE,

CHKHAIDZE

et al. 2016

JTST

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On the basis of natural aminoacids: L-leucine, L-phenylalanine, L-lysine are received co-polyesteramides containing n-alkyl groups (octyl (Oct), dodecyl (Dod) and hexadecyl (Hex)) in AABB-type lateral chain. Co- polyesteramides are received virtually in quantitative yield, with very high molecular masses and narrow molecular-mass distribution.This is an important fact from the viewpoint of their use for the biomedical purposes.Mechanical properties of some polymers are studied by us. Study of thermal and mechanical properties of polymers is important for polymers for biomedicine purposes, since they have impact on many other properties of polymers, including biodegradation capacity and they are respectively precondition for the sphere of their application.

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Section: Characterization and Properties Of Polyesteramides Containin...mentioning

confidence: 99%

Characterization and Properties of Polyesteramides

LOLADZE,

NEPARIDZE,

CHKHAIDZE

et al. 2016

JTST

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“…The synthesis of polyamides containing lactam units in the main chain can be attempted in two ways: ring-opening polymerization − of bicyclic dilactams and the polycondensation of monomers containing the lactam unit. Presented here are the improved preparation and attempts at ring-opening polymerization of the bicyclic lactam 2,5-diazabicyclo[2.2.2]octane-3,6-dione (2,5-DBO).…”

Section: Introductionmentioning

confidence: 99%

“…[10][11][12][13][14][15] This is a very active current area of research in which the techniques of multidimensional NMR and molecular dynamics provide the most common methods of probing conformations associated with βand γ-turn structures. [16][17][18][19][20][21][22][23][24] The synthesis of polyamides containing lactam units in the main chain can be attempted in two ways: ringopening polymerization [25][26][27][28][29][30] of bicyclic dilactams and the polycondensation of monomers containing the lactam unit. Presented here are the improved preparation and attempts at ring-opening polymerization of the bicyclic lactam 2,5-diazabicyclo[2.2.2]octane-3,6-dione (2,5-DBO).…”

Section: Introductionmentioning

confidence: 99%

Synthesis and NMR Studies of Activated Derivatives ofcis- andtrans-5-Amino-6-oxopiperidine-2-carboxylic Acid and the Corresponding Bicyclic Dilactam 2,5-DBO: Potential Building Blocks for Stereoregular Polyamides and Peptides

et al. 1999

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Presented here are the syntheses of bicyclodilactams as precursors of polymeric lactams. A new preparation for the 2,5-diazabicyclo[2.2.2]octa-3,6-dione was developed. The four possible dimers were prepared from the N-protected cis- and trans-5-amino-6-oxopiperidine-2-carboxylates (Apc's). Base treatment of the trans activated ester led to the polymer. Synthesis of the isomeric 2,6-diazabicyclo[2.2.2]octan-3,5-dione was not successful even under conditions in which substituted compounds were found. From the 1H NMR spectral data for the monomers and dimers, we concluded that the H−H coupling constants for the cis- and trans-Apc monomers are consistent with the low-energy pseudo-chair conformations inferred from structures optimized at the B3PW91/6-31G* level of density functional theory. The two-dimensional NMR spectra of the oligomers give no evidence for β-turn formation in DMSO-d 6.

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Synthesis of heterochain polymers using chemically activated monomers (“Activated polycondensation”). Review

Cited by 2 publications

References 66 publications

Characterization and Properties of Polyesteramides

Characterization and Properties of Polyesteramides

Synthesis and NMR Studies of Activated Derivatives ofcis- andtrans-5-Amino-6-oxopiperidine-2-carboxylic Acid and the Corresponding Bicyclic Dilactam 2,5-DBO: Potential Building Blocks for Stereoregular Polyamides and Peptides

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