Synthesis of heteroaryl C-glycosides via Ru-catalyzed C–H activation/cyclization: dioxazolone glycogen designs and applications

Abstract

New glycogen reagents of dioxazolones glycogen anomeric have been developed. The versatile heteroarene C-glycosides have been synthesized using a Ru-catalyzed C-H activation/annulation strategy, employing these dioxazolones glycogen anomeric. These reactions...

Assembly of Heterocyclic C-Glycosides by Ru-Catalyzed C–H Activation/Cyclization with Carbonyl Sulfoxonium Ylide Glyco-Reagents

“…We aim to address challenges in the synthesis of C-heteroaryl glycosides from two perspectives: (a) addressing the issue of diversity in the synthesis of heteroarenes of C-glycosides and (b) controlling the stereoselectivity of C-glycosides by manipulating the substrate’s stereoselectivity. Recently, our research group is interested in the metal-catalyzed C–H activation/cyclization strategy for synthesizing heterocyclic compounds . We hope to develop novel glycoside reagents that possess the following attributes: (a) stability, (b) stereoselectivity, (c) ability to initiate cascade reactions, and (d) high reactivity.…”