Synthesis of Grisan and Coumaran-3-one Derivatives with Potential Insect-Repellent Properties¹

Antidermatophytic Properties of Griseofulvin Derivatives with Potential Systemic Insect-Repellent Activity

“…Keyphrases 0 Ethylene oxide sterilized plastic, rubber-2-chloroethanol determination 0 2-Chloroethanol extraction, determination-surgical materials 0 GLC-analysis Methods for the determination of 2-chloroethanol (ethylene chlorohydrin) in foods, plastic, and rubber have recently appeared in the literature (1)(2)(3)(4)(5). We have found these methods to be unreliable for this determination in polyvinyl chloride plastic (PVC), and in synthetic and latex rubber.…”

“…IVa, decanoic acid: IVb, 449- 1 All of the evaluants were provided by Drs. R. P. Quintana Clinical isolates of Trichophyton rubrum and mentagrophytes, Epidermophyton Jloccosum, Microsporum canis and gypseum were maintained in serial culture by standard techniques.…”

“…The synthesis and physicochemical evaluation of a number of grisan and coumaranone derivatives designed as potential systemic insect repellents have been reported (1)(2)(3). In this communication, the in uitro antidermatophytic properties of these compounds were evaluated with the expectation that the data could I (grineofulvin) I 0 provide a basis for their quantitative determination in dermal tissue.…”

Monomolecular films of compounds with potential dermophilic and prophylactic properties. Esters of dihydroxyacetone

“…During the past few years, we have been concerned with the development of agents exerting perdurable insect-repellent and other types of prophylactic activity subsequent to topical or systemic administration (1)(2)(3)(4)(5)(6). Currently, our efforts are focused on compounds designed to provide long-lasting prophylactic efficacy by rneails of the gradual release of an active component from a precursor-type molecule anchored to the epidermal surface (3).…”

Synthesis of phenolic esters with potential long-lasting insect-repellent properties

“…In the course of the synthetic work two compounds (10 and 11) were obtained which, not being esters, cannot release undecanoic acid. They constitute excellent control entities (pseudo precursor-type molecules), however, for our evaluation of relative intrinsic repellencies and of relative dermophilic characteristics; in fact, they are better suited for the task than the ones originally designed for this purpose (1,3,4, and 5).…”