Synthesis of gold–silica core–shell nanoparticles by pulsed laser ablation in liquid and their physico-chemical properties towards photothermal cancer therapy

Riedel, R.; Mahr, Nora; Yao, Changliang; Wu, Aiguo; Yang, Fang; Hampp, Norbert

doi:10.1039/c9nr07129f

Cited by 48 publications

(33 citation statements)

References 64 publications

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“…Therefore, the development of convenient, high-efficiency methods is necessary, in order to scale up production. Recently, Riedel et al (2020) synthesized spherical, silica-coated AuNPs, with an average diameter of 9 nm and a coating thickness of 2 nm, by improved pulsed laser ablation in liquid (PLAL), and this method offers great progress to the large-scale production of nanoparticles. Another promising method for synthesis of AuNPs is ion implantation, which has been extensively used to prepare AuNPs with precise physical, chemical, and biological properties.…”

Section: Synthesis and Modification Of Multifunctional Aunpsmentioning

confidence: 99%

Multifunctional Gold Nanoparticles: A Novel Nanomaterial for Various Medical Applications and Biological Activities

Zhang

Ding

et al. 2020

Front. Bioeng. Biotechnol.

354

206

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Nanotechnology has become a trending area in science and has made great advances with the development of functional, engineered nanoparticles. Various metal nanoparticles have been widely exploited for a wide range of medical applications. Among them, gold nanoparticles (AuNPs) are widely reported to guide an impressive resurgence and are highly remarkable. AuNPs, with their multiple, unique functional properties, and easy of synthesis, have attracted extensive attention. Their intrinsic features (optics, electronics, and physicochemical characteristics) can be altered by changing the characterization of the nanoparticles, such as shape, size and aspect ratio. They can be applied to a wide range of medical applications, including drug and gene delivery, photothermal therapy (PTT), photodynamic therapy (PDT) and radiation therapy (RT), diagnosis, X-ray imaging, computed tomography (CT) and other biological activities. However, to the best of our knowledge, there is no comprehensive review that summarized the applications of AuNPs in the medical field. Therefore, in this article we systematically review the methods of synthesis, the modification and characterization techniques of AuNPs, medical applications, and some biological activities of AuNPs, to provide a reference for future studies.

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Section: Synthesis and Modification Of Multifunctional Aunpsmentioning

confidence: 99%

Multifunctional Gold Nanoparticles: A Novel Nanomaterial for Various Medical Applications and Biological Activities

Zhang

Ding

et al. 2020

Front. Bioeng. Biotechnol.

354

206

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“…Tumor cell death is induced when a temperature of at least 43 • C is obtained inside the tumor mass for a period of 15 min. By utilizing pulsed laser ablation, the laser irradiation power and the different concentrations of AuNPs [19]. Coating gold NPs with silica has a shape-conserving effect, preventing gold NPs from deforming following laser irradiation [20].…”

Section: Aunps and Photothermal Therapy In Oncologymentioning

confidence: 99%

“…Regarding the photothermal efficiency of AuNPs, tumor cells containing gold-silica NPs undergo cell death by apoptosis during photothermal treatment. Moreover, the efficiency of gold-silica NPs might be increased by surface silanization with tumor cell ligands specific for each tumor entity, allowing a more specific approach toward different biomedical applications in oncology [19]. The combination of AuNPs-based photothermal therapy with other anticancer therapies, which allows the use of multiple mechanisms that target the growth and survival pathways of tumor cells, might represent a key for improving treatment outcomes in multiple fields of oncology [21].…”

Section: Aunps and Photothermal Therapy In Oncologymentioning

confidence: 99%

“…To this end, new strategies are emerging for the large-scale production of AuNPs. Among these, pulse laser ablation in liquid (PLAL) probably represents the future of NP synthesis, being able to produce NPs in solution, increasing the stability and integrity of gold nanoparticles [19]. The improvements in the future, the possibility of obtaining AuNPs with a wide range of shapes and sizes, from spherical to bone-shaped, with different physicochemical properties, which will allow their application in multiple fields of oncology [10].…”

Section: Concluding Remarks: the Future Of The Aunps In Oncologymentioning

confidence: 99%

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Gold Nanoparticles: A New Golden Era in Oncology?

et al. 2020

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In recent years, the spectrum of possible applications of gold in diagnostics and therapeutic approaches in clinical practice has changed significantly, becoming surprisingly broad. Nowadays, gold-based therapeutic agents are used in the therapy of multiple human diseases, ranging from degenerative to infectious diseases and, in particular, to cancer. At the basis of these performances of gold, there is the development of new gold-based nanoparticles, characterized by a promising risk/benefit ratio that favors their introduction in clinical trials. Gold nanoparticles appear as attractive elements in nanomedicine, a branch of modern clinical medicine, which combines high selectivity in targeting tumor cells and low toxicity. Thanks to these peculiar characteristics, gold nanoparticles appear as the starting point for the development of new gold-based therapeutic strategies in oncology. Here, the new gold-based therapeutic agents developed in recent years are described, with particular emphasis on the possible applications in clinical practice as anticancer agents, with the aim that their application will give rise to a new golden age in oncology and a breakthrough in the fight against cancer.

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“…These types of nanoshells appear to be promising for cancer treatment, as their optical properties have a changeable plasmon resonance in the NIR region [55]. Specific types of AuNSh have size limitations and can potentially form by-products during the fabrication process that can negatively interfere with the hyperthermia treatment [64,55]. A key disadvantage for the use of polystyrene latex cores is that their resonances cannot produce sufficient heat to kill cancer cells in tumours [55].…”

Section: Selective Photothermal-induced Cell Deathmentioning

confidence: 99%

Comparison of Four Common Gold Nanoparticles for Photothermal Cancer Therapy: A Review

Saiphoo

Rose

Dunn

et al. 2020

IJEMM

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Current cancer treatment options, including surgery, chemotherapy and radiation therapy, often cause damage to healthy tissue and reduce a patient's quality of life with well-known side effects, such as pain, infection and nerve damage. Recent research has shown that gold nanoparticles used as photothermal agents in photothermal therapy may pose as an alternative to traditional treatments. This great potential is due to their ability to selectively accumulate in cancerous tissue, efficiently absorb near-infrared light, and kill cancerous tissue without harming surrounding cells. Gold nanoparticles show promise in increasing treatment efficacy and reducing the side effects associated with cancer therapy. While recent studies show the potential of gold nanoparticles, the existing literature is limited in drawing comparisons between studies and practical use for photothermal therapy. This paper reviews notable studies on four common gold nanoparticles used in the therapeutic treatment of cancer: gold nanocages, gold nanospheres, gold nanorods, and gold nanoshells. By comparing key characteristics of the particles’, including their synthesis, toxicity, absorption spectrum, and selective photothermal lethality, gold nanospheres can be recommended for use in photothermal therapy. Although forms of each gold nanoparticle were found to have a low toxicity, gold nanospheres can be rapidly synthesized and appear to exceed in selective photothermal lethality and immature tumour accumulation. Due to these advantages in using gold nanospheres for photothermal therapy, cancer could be treated more effectively and improve patient prognosis.

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Synthesis of gold–silica core–shell nanoparticles by pulsed laser ablation in liquid and their physico-chemical properties towards photothermal cancer therapy

Abstract: Due to the increasing scientific and biomedical interest in various nanoparticles (NPs) showing excellent properties, a convenient and adjustable physical method with improved efficiency needs to be used for enabling tech-scale production of such promising NPs.

Cited by 48 publications

References 64 publications

Multifunctional Gold Nanoparticles: A Novel Nanomaterial for Various Medical Applications and Biological Activities

Multifunctional Gold Nanoparticles: A Novel Nanomaterial for Various Medical Applications and Biological Activities

Gold Nanoparticles: A New Golden Era in Oncology?

Comparison of Four Common Gold Nanoparticles for Photothermal Cancer Therapy: A Review

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