Synthesis of gold nanoparticles using Sambucus wightiana extract and investigation of its antimicrobial, anti-inflammatory, antioxidant and analgesic activities

Khuda, Fazli; Haq, Zafar Ul; Ilahi, Ihsan; Ullah, Rahim; Khan, Aisha; Fouad, H.; Ullah, Zaki; Sahibzada, Muhammad Umar Khayam; Shah, Yatrik M.; Abbas, Muhammad; Iftikhar, Tayyaba; Batiha, Gaber El‐Saber

doi:10.1016/j.arabjc.2021.103343

Cited by 26 publications

(5 citation statements)

References 30 publications

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“…DPPH assay with a few minor modifications was used to determine the antioxidant potential of extracts [ 23 ]. To make a 0.01-mM DPPH solution, 4 mg of DPPH was dissolved in 100 mL methanol.…”

Section: Methodsmentioning

confidence: 99%

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Anatomical Characterization, HPLC Analysis, and Biological Activities of Ilex dipyrena

Ali

Nisar

Shah

et al. 2022

Plants

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Ilex dipyrena Wall (Aquifoliaceae), is a traditional medicinal plant abundantly found in India and Pakistan. In the current research work, initially, the anatomical characteristics were recorded through microscopic examination of selected plant parts, such as leaf, petiole, and midrib. Then, the quantitative phytochemical screening was performed using standard tests reported in literature. The whole-plant powdered sample was then soaked in methanol to obtain crude extract, which was then fractionated into solvents of different polarities to obtain ethyl acetate, chloroform, butanol, hexane, and aqueous extracts. The phytochemical composition of the crude ethyl acetate and chloroform extracts (being the most active fractions) was then confirmed through HPLC analyses, where the possible phytochemical present were predicted through comparison of retention time of a given compound peak with the available standards. The extracts were also evaluated for their in vitro antioxidant and ani-lipoxygenase potentials using standard methods. The microscopic examination revealed the presence of anomocytic type stomata on the abaxial side of the leaf as well as unicellular trichrome and calcium oxalate druses crystals in the midrib and petiole, with a single, centered U-shaped collateral arterial bundle, which was directed toward the adaxial and the phloem toward the abaxial sides of the selected plant parts, respectively. Almost all tested representative groups of phytochemicals and essential minerals were detected in the selected plant, whereas five possible phytochemicals were confirmed in crude and chloroform extract and seven in ethyl acetate fraction. As antioxidant, chloroform fraction was more potent, which exhibited an IC50 value of 64.99, 69.15, and 268.52 µg/mL, determined through DPPH, ABTS, and FRAP assays. Ethyl acetate extract was also equally potent against the tested free radicals. Chloroform and ethyl acetate extracts were also potent against lipoxygenase, with IC50 value of 75.99 and 106.11 µg/mL, respectively. Based on the results of biological studies, Ilex dipyrena was found to good inhibitor of free radicals and lipoxygenase that could be further investigated to isolate compounds of medicinal importance.

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Section: Methodsmentioning

confidence: 99%

“…The extract and fractions volume of 300 µL were mixed with 3 mL of ABTS solution and incubated for 6 min. The absorbance was recorded in triplicate at 745 nm, whereas tocopherol was used as standard following same procedure as described above [ 23 ].…”

Section: Methodsmentioning

confidence: 99%

Anatomical Characterization, HPLC Analysis, and Biological Activities of Ilex dipyrena

Ali

Nisar

Shah

et al. 2022

Plants

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“…The as‐synthesized Au NPs exhibited dose‐dependent analgesic behavior, which is significant at a dosage of 20 mg kg −1 (56.22%). [ 40 ] In a different study, Raimundo et al produced Gold NPs in an ecofriendly manner and then gave them to male and female Swiss mice to test their analgesic and anti‐inflammatory effects. This work established the anti‐inflammatory and peripheral analgesic effects of Au NPs since these signaling pathways may or may not be connected.…”

Section: Mechanism Of Antibacterial Anti‐inflammatory and Analgesic A...mentioning

confidence: 99%

“…Citrate protected Au NPs [ 64] 20 nm In vivo alterations on microvascular system -Biosynthesized using the Sambucus wightiana extract [ 40] 15 nm 1. In vitro COX-2 assay 2.…”

mentioning

confidence: 99%

A Comprehensive Review on Antibacterial, Anti‐Inflammatory and Analgesic Properties of Noble Metal Nanoparticles

Aswathy Waliaveettil,

Anila

2023

Part & Part Syst Charact

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Their health industry is facing challenges due to a rise in mortality rates brought on by various multi‐drug‐resistant bacterial strains. As a result, new and improvedantibacterial drugs are urgently needed. Similarly, when some unwanted foreign pathogensenter the cellular premises to disturb its homeostasis, inflammation develops as an immune reaction. However, these immune responses also become a double‐edged sword when the inflammatory reaction lasts for a long time, and pain is also linked to inflammatory responses. Inflammation and pain are both signs of tissue injury. Pain is,by definition, an unpleasant experience that ultimately interferes with their normalwell‐being. Hence, bacterial infection, inflammation, and pain need medical assistance to maintain homeostasis. Conventional medicines possess so many repercussive effects, which then demand a replacement with a less toxic and more efficient modern drug. In their review article, for the first time, they present recent advancements in biomedical applications such as the antimicrobial, anti‐inflammatory, and analgesic properties of noble metal nanoparticles. Noble metals have limited availability in the earth's crust. Hence, their physicochemical characterizations and applications are greatly limited. Still, there are some interesting research findings that offer a significant ray of hope for the health sector all over the world.

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“…As was discussed in the previous section, these NPs exhibit a variety of pharmacological properties such as antiin ammatory [6], antibacterial [7], antihelminthic [8], antioxidant [9], antiviral [10], anticancer [11], and antifungal properties [12]. In addition, compounds derived from natural sources that are known for their anticancer e ects include vincristine, vinblastine, paclitaxel, and camptothecin, as well as their derivatives [13].…”

Section: Introductionmentioning

confidence: 99%

An Overview on Rumex dentatus L.: Its Functions as a Source of Nutrient and Health-Promoting Plant

Zeb

Khan

Shah

et al. 2022

Evidence-Based Complementary and Alternative Medicine

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Rumex dentatus L. (Polygonaceae), also known as toothed dock or Aegean dock, is a medicinal plant with a high culinary value in addition to being used as an ethnomedicinal plant. This review focuses on the botanical, nutritional, phytochemical, and pharmacological activities of R. dentatus, as well as the future prospects for systematic investigations into these areas. R. dentatus has been subjected to scientific evaluation, which has confirmed its traditional uses and demonstrated a wide range of biological and pharmacological potentials, including antioxidant, anticancer, antifungal, antibacterial, anti-inflammatory, and other biological properties. Phytochemical analyses showed the presence of anthraquinones, chromones, flavonoids, and essential oils. As a result of this current review, the medicinal significance of R. dentatus has been confirmed, and future research on its unexplored aspects, such as the identification of pharmacologically active chemical constituents and related mechanisms and safety, may be stimulated, with the goal of developing it into a drug.

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Synthesis of gold nanoparticles using Sambucus wightiana extract and investigation of its antimicrobial, anti-inflammatory, antioxidant and analgesic activities

Cited by 26 publications

References 30 publications

Anatomical Characterization, HPLC Analysis, and Biological Activities of Ilex dipyrena

Anatomical Characterization, HPLC Analysis, and Biological Activities of Ilex dipyrena

A Comprehensive Review on Antibacterial, Anti‐Inflammatory and Analgesic Properties of Noble Metal Nanoparticles

An Overview on Rumex dentatus L.: Its Functions as a Source of Nutrient and Health-Promoting Plant

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