Synthesis of gold nanoparticles by pulsed laser-assisted reduction of aqueous gold precursor

Sahebi, Fateme; Ranjbar, M.; Goodarzi, Mehdi Torabi

doi:10.1007/s00339-019-3138-z

Cited by 5 publications

(3 citation statements)

References 70 publications

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“…By exploiting the formation of Au 0 as a marker for notable radiolysis, these observations demonstrate that this effect must be considered even when specimen are exposed to low dose rates. These findings are in-line with further studies on gold reduction observed in photon-mediated radiation chemistry caused by lasing, [75,76] UV exposure, [77] or 𝛾-irradiation, [54,59,60,[78][79][80][81] mostly performed at dose rates many orders of magnitude lower than those utilized in synchrotron-beam lines or experiments.…”

Section: Dose Rate Requirements For Gold Nanostructure Growthsupporting

confidence: 86%

Radiolysis‐Driven Evolution of Gold Nanostructures – Model Verification by Scale Bridging In Situ Liquid‐Phase Transmission Electron Microscopy and X‐Ray Diffraction

et al. 2022

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Utilizing ionizing radiation for in situ studies in liquid media enables unique insights into nanostructure formation dynamics. As radiolysis interferes with observations, kinetic simulations are employed to understand and exploit beam‐liquid interactions. By introducing an intuitive tool to simulate arbitrary kinetic models for radiation chemistry, it is demonstrated that these models provide a holistic understanding of reaction mechanisms. This is shown for irradiated HAuCl4 solutions allowing for quantitative prediction and tailoring of redox processes in liquid‐phase transmission electron microscopy (LP‐TEM). Moreover, it is demonstrated that kinetic modeling of radiation chemistry is applicable to investigations utilizing X‐rays such as X‐ray diffraction (XRD). This emphasizes that beam‐sample interactions must be considered during XRD in liquid media and shows that reaction kinetics do not provide a threshold dose rate for gold nucleation relevant to LP‐TEM and XRD. Furthermore, it is unveiled that oxidative etching of gold nanoparticles depends on both, precursor concentration, and dose rate. This dependency is exploited to probe the electron beam‐induced shift in Gibbs free energy landscape by analyzing critical radii of gold nanoparticles.

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Section: Dose Rate Requirements For Gold Nanostructure Growthsupporting

confidence: 86%

Radiolysis‐Driven Evolution of Gold Nanostructures – Model Verification by Scale Bridging In Situ Liquid‐Phase Transmission Electron Microscopy and X‐Ray Diffraction

et al. 2022

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“…Sahebi et al (2019) reported the fabrication of colloidal GNPs using pulsed laser ablation reduction of aqueous gold precursor. 49 By applying the laser ablation approach with a low-power neodymium yttrium aluminum garnet (Nd:YAG) laser at the fundamental wavelength, high-purity GNPs have been effectively produced by Khumaeni et al 50 In order to create GNPs, an experimental pulse laser beam was focused onto a high-purity gold sheet, which was then placed into deionized water. GNPs were produced in tetrahydrofuran utilizing the pulsed laser ablation approach in another investigation.…”

Section: Laser Ablation Synthesis Of Gnpsmentioning

confidence: 99%

Rise of Gold Nanoparticles as Carriers of Therapeutic Agents

Thalluri,

Swain,

Pattnaik

2023

ACSi

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Nanoparticles are typically nanoscopic materials with at least one of the dimensions below 100 nm having diverse applications in many industries. The latest developments in nanotechnology provide a wide range of methods for studying and monitoring various medical and biological processes at the nanoscale. Nanoparticles can help diagnose and treat diseases, such as cancer, by carrying drugs directly to cancer cells. They can also be used to detect disease biomarkers in the body, helping to provide early diagnosis. It is plausible that nanoparticles could be used in theranostic applications and targeted drug delivery. This could significantly improve patient outcomes and reduce the amount of time, effort, and money needed to diagnose and treat diseases. It could also reduce the side effects of treatments, providing more precise and effective treatments. Nanoparticles for biomedical applications include polymeric and metal nanoparticles; liposomes and micelles; dendrimers and quantum dots; etc. Among the nanoparticles, gold nanoparticles (GNPs) have emerged as a promising platform for drug delivery applications. GNPs are highly advantageous for drug delivery applications due to their excellent biocompatibility, stability, and tunable physical and chemical properties. The present review provides an in-depth discussion of the various approaches to GNPs synthesis and drug delivery applications.

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“…In long-term usage, this procedure also produces toxicity, which complicates its in-vivo applications. Furthermore, no universal reducing agents have been identified to produce monodisperse AuNPs [ 19 ].…”

Section: Introductionmentioning

confidence: 99%

Antibody-labelled gold nanoparticles synthesized by laser ablation to detect SARS-CoV-2 antigen spike

Sulfianti,

Tiara Sopandi,

Isnaeni

et al. 2023

ADMET DMPK

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Background and purpose: Rapid detection test via lateral flow immunoassay (LFIA) is employed as an alternate method to detect Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) infection. Gold nanoparticles (AuNPs), a vital component of LFIA, can be synthesized by laser ablation technique. This intense laser radiation may result in monodisperse gold nanoclusters, which are impurity-free and demonstrate innovative biocompatible surface chemistry. In this current research, laser-ablated AuNPs are produced and coupled with an anti-spike SARS-CoV-2 monoclonal antibody (mAb) generated in our prior study. Experimental approach: The AuNPs from 30,000 shots of laser ablation exhibited a robust red color with a maximum absorbance peak at 520 nm. The performance of AuNPs-mAb conjugates as a signal reporter was then evaluated in half-stick LFIA. Key results: The size distribution of AuNPs shows a relatively monodisperse and unimodal distribution with average particle diameters of 44.77 nm and a surface potential of -38.5 mV. The purified anti-spike mAb SARS-CoV-2 yielded two protein bands, representing the mAb heavy chain at 55 kDa and its light chain at 25 kDa. The immobilization of anti-spike mAb onto the surface of AuNPs revealed that 25 g/ml of mAb at phosphate buffer pH 9 was required to stabilize the AuNPs. The functional test of this conjugate was performed using dipstick LFIA, and the result shows that the AuNPs-mAb conjugates could successfully detect commercial spike antigen of SARS-CoV-2 at 10 ng level. Conclusion: In this study, laser-ablated AuNPs were functionalized with anti-spike mAb SARS-CoV-2 and successfully used as a signal reporter in half-stick LFIA for detecting antigen spike SARS-CoV-2.

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Synthesis of gold nanoparticles by pulsed laser-assisted reduction of aqueous gold precursor

Cited by 5 publications

References 70 publications

Radiolysis‐Driven Evolution of Gold Nanostructures – Model Verification by Scale Bridging In Situ Liquid‐Phase Transmission Electron Microscopy and X‐Ray Diffraction

Radiolysis‐Driven Evolution of Gold Nanostructures – Model Verification by Scale Bridging In Situ Liquid‐Phase Transmission Electron Microscopy and X‐Ray Diffraction

Rise of Gold Nanoparticles as Carriers of Therapeutic Agents

Antibody-labelled gold nanoparticles synthesized by laser ablation to detect SARS-CoV-2 antigen spike

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