Synthesis of furo[2,3-c]-2,7-naphthyridine derivatives via domino heterocyclization reaction

Epihalohydrins in Organic Synthesis

“…Tverdokhlebov and co-workers have investigated the coupling of 2-amino-4-cyanomethyl-6-dialkylamino-3,5-pyridinedicarbonitriles ( 171 ) with epichlorohydrin ( 5 ) in the presence of K 2 CO 3 to yield 1,2-dihydrofuro[2,3- c ]-2,7-naphthyridine derivatives 173 via a domino heterocyclization reaction (Scheme ) …”

Regioselective, one-pot, multi-component, green synthesis of substituted benzo[c]pyrazolo[2,7]naphthyridines

“…Studies in the literature reveal that many of the benzo[c] [2,7] naphthyridine derivatives [17][18][19][20][21] have been synthesized employing new strategies to investigate the potential of fused ve membered heterocycles such as isoxazolo-, 22 cyclopenta-, 23 pyrazolo-, 24 imidazo- 25 and furo- 26,27 annulated 2,7-naphthyridines. Numerous reported elegant reactions that oen involved multistep harsh reaction conditions using organic solvents and homogenous or heterogeneous catalysts.…”