Synthesis of Furans – Recent Advances

Deepthi, Ani; Babu, Beneesh P.; Balachandran, Aswathy L.

doi:10.1080/00304948.2019.1633228

Cited by 42 publications

(28 citation statements)

References 121 publications

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“…Furan which is found in many natural products and display diverse pharmaceutical activities is also used as a significant building block in the synthetic organic chemistry over a long period of time. Therefore, in recent years, considerable strives have been devoted towards the synthesis of furan and its congeners . Among the available methods for its synthesis, the most popular are Paal‐Knorr and Feist‐Benary furan synthesis.…”

Section: Applications Of Rongalite Chemistry In Organic Synthesismentioning

confidence: 99%

New Dimensions in Rongalite Chemistry: The Land of Opportunities in Organic Synthesis and Material Sciences

Ali

2020

ChemistrySelect

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Rongalite, first time reported in the chemical structure in 1905, also known as bruggolite or sodium formaldehyde sulfoxylate, having good solubility and stability in organic media, is not only a cheap and commercially available (in kg amount) reagent with a range of industrial applications for instance emulsion polymerization, an excellent decolouring agent, antioxidant in pharmaceutical development, and an antidote for heavy metals, but also used as an effective regents in a plethora of organic reactions particularly in redox reactions as a powerful reducing agent. More interestingly, in recent years, it has also shown its impact in material sciences for the preparation of CdTe, CoTe2, and Ag2Se thin films, nanowire networks, hollow nanospheres, copper nanoparticles (Cu‐Nps), CdTe‐quantum dots and so forth. Keeping in mind the importance of this vital reagent in both organic chemistry as well as in material sciences, herein I intended to report the recent developments along with a brief overview of old literature wherever necessary to showcase the utility of this valuable reagent. This particular review article not only covers the applications of this environmentaly benign reagent in organic synthesis but also its usefulness in material sciences in particular nanosciences has been exposed for the first time.

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Section: Applications Of Rongalite Chemistry In Organic Synthesismentioning

confidence: 99%

New Dimensions in Rongalite Chemistry: The Land of Opportunities in Organic Synthesis and Material Sciences

Ali

2020

ChemistrySelect

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“…17 Allenes are considered to be crucial building blocks in heterocyclic compounds synthesis due to their unique structures and multiple active sites, [18][19][20][21] which are still the least studied allcarbon unsaturated functional groups. 22,23 Since the discovery of the two classical methods, chemists have developed many groundbreaking methods for the synthesis of tetrasubstituted furans, some of which rely on the annulation of allenes [24][25][26][27][28][29][30][31] (Scheme 1). Despite the availability of the reported methods, there are some limitations.…”

Section: Introductionmentioning

confidence: 99%

Electrochemically-mediated C–H functionalization of allenes and 1,3-dicarbonyl compounds to construct tetrasubstituted furans

Yao

et al. 2022

Org. Chem. Front.

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“…[34] Furan produced by Paal-Knorr synthesis through a cyclization of 1,4-diones and the classical Fensi-Benary procedure ChemistrySelect between α-halo carbonyl compounds and 1,3-dicarbonyl compounds. [35] Various furans and its derivatives exhibited biological and pharmacological activities such as: anti-cancer, anti-microbial, anti-neoplastic and anti-diabetic, anti-depressant, anti-anxiolytic, analgesic, anti-inflammatory, muscle relaxant, ant-hypertensive, anti-arrhythmic, anti-fungal, anti-viral, anti-aging agents, anti-ulcer, anti-histaminic, anti-cholinergic, anti-parkinsonism, anti-diuretic, and inhibition of sickle cell formation, these properties make synthesis of furans attractive and also important in experimental researches. [36] In recent years, protocols for synthesis of functional furan derivatives have been well documented in the literature.…”

Section: Furansmentioning

confidence: 99%

Use of Dialkyl Acetylenedicarboxylates in the Multicomponent Synthesis of Heterocyclic Structures

2022

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Dialkyl acetylenedicarboxylates (DAAD) are the class of acetylenic compounds that are broadly used in organic synthesis in a noticeable quantity. Their wide application has made them an important moiety in heterocyclic compounds and drug discovery programs. Dialkyl acetylenedicarboxylate is a di-ester in which the ester groups are conjugated with a carbon-carbon triple bond. As such, the molecule is very electrophilic, and is broadly used as a dienophile in various cycloaddition reactions, for example the Diels-Alder reaction. In addition, it is a strong Michael acceptor. Due the importance of dialkyl acetylenedicarboxylate in organic synthesis, we are trying to show the applications of this compound in the synthesis of different heterocycles using multicomponent reactions. In this review, we show recent advances (2016)(2017)(2018)(2019)(2020)(2021)(2022) for the synthesis of various heterocycles that have different ring sizes (five, six and seven membered, Spiro and fused heterocycles), using DAAD via multicomponent reactions.

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Synthesis of Furans – Recent Advances

Cited by 42 publications

References 121 publications

New Dimensions in Rongalite Chemistry: The Land of Opportunities in Organic Synthesis and Material Sciences

New Dimensions in Rongalite Chemistry: The Land of Opportunities in Organic Synthesis and Material Sciences

Electrochemically-mediated C–H functionalization of allenes and 1,3-dicarbonyl compounds to construct tetrasubstituted furans

Use of Dialkyl Acetylenedicarboxylates in the Multicomponent Synthesis of Heterocyclic Structures

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