Synthesis of functionalized tetrahydrodibenzo[b,g][1,8]naphthyridin-1(2H)-ones through base-promoted annulation of quinoline-derived dipolarophiles and cyclic enaminones

Abstract

An eco-friendly and metal-free method for the tetrahydrodibenzo[b,g][1,8]naphthyridin-1(2H)-ones was establish. Quinoline derived dipolarophiles and cyclic enaminones as starting materials pass 1,4-Michael addition/SNAr tandem annulation reaction afford the target products. The...