Synthesis of functionalized benzo[f]2H-chromenes and evaluation of their antimicrobial activities

Application of the aza‐Wittig reaction for efficient synthesis of diversely substituted benzo[f]Chromeno[2,3‐d]pyrimidine and benzo[f]chromeno[2,3‐d][1,2,4]triazolopyrimidine derivatives

“…Owing to their broad spectrum of biological activities, chromenes serve as potential antileishmanial [2], antiviral [3], antifungal [4], antimalarial [5], antioxidant [6], antimicrobial [7], anti-HIV [8], and antitumor [9,10] activities. Furthermore, fused chromenes are also privileged scaffolds exhibiting diverse biological activities.…”

Synthesis, Characterization, Antimicrobial, DNA Cleavage and Fluorescent Activity of Metal ion(II) Coordinate with 2H-Chromene Azo novel ligand

“…Heterocyclic compounds represent a large family of organic compounds (Katritzky et al, 2010;Brimble et al, 2008), they are known for widespread applications in various ields because of their biological importance, medicinal chemistry, and chemical biology. The 2H-chromene (2H-1-benzopyran) moiety is one of the most important heterocycles detected in many biologically active natural products and in synthetic compounds (Kolokythas et al, 2007;P et al, 2009;Schweizer and Meeder, 1977) 2H-chromenes were reported to display signi icant antioxidant (Kwak et al, 2006) , antiviral (Martínez-Grau and Marco, 1997) , antimicrobial (Li et al, 2018) anti-in lammatory (Gebhardt et al, 2007) and antifungal (Chanu et al, 2017) properties, in addition to their interesting applications as highly effective luorescent dyes (Moorthy et al, 2006) Furthermore, several metal complexes of chromene derivatives possess antimicrobial (Soliman et al, 2016) DNA cleavage activities (Prabhakara et al, 2015) and photoluminescence properties (Aazam et al, 2012) . Azo compounds and their complexes are highly important due to their applications as textile dyes , Zhigang et al (2009) indicators (Abbas et al, 2018) , medicinal importance (Philip et al, 2019) and are also inhibition of DNA, RNA and protein cre-ation (Park et al, 2007) In the present study, we display the synthesis and characterization of Co(II), Cu(II), and Ni(II) complexes with new azo-linked chromene ligand (AH).…”

Synthesis of bioactive heterocycles using reusable heterogeneous catalyst HClO4–SiO2 under solvent-free conditions

“…Our group has long-standing interest on the synthesis of bioactive heterocycles (27)(28)(29) using β-oxodithioesters as synthon (30). We are reporting herein the application of silica-supported perchloric acid HClO 4 -SiO 2 as an effective catalyst in solvent-free synthesis of chromenes by Knoevenagel condensation and dihydropyrimidinone by Biginelli type reaction using β-oxodithioesters as common starting material (Scheme 1).…”