Synthesis of fully substituted pyrazolo[3,4-b]pyridine-5-carboxamide derivatives via a one-pot four-component reaction

Stereoselective Synthesis of 1′,5′,7′,8′-Tetrahydro-2′H,4′H-Dispiro[[1,3] Dioxane-5,3′-Quinoline-6′,5″-[1″,3″]Dioxane]-4,4″,6,6″-Tetrone Derivatives in the Presence of Benzoic Acid as an Efficient Catalyst Via One-Pot Multicomponent Reaction

“…1′,5′,7′,8′-Tetrahydro-2′H,4′H-dispiro[ [1,3] We tried to optimise the amount of catalyst at ambient temperature for the synthesis of these dispiro compounds using Meldrum's acid, arylamines and aromatic aldehydes. It was found that the best reaction conditions were obtained with 18.2% solution of benzoic acid.…”

“…In conclusion, a highly efficient method has been developed for the synthesis of 1′,5′,7′,8′-tetrahydro-2′H,4H-disporo[ [1,3] dioxane-5,3′-quinoline-6′,5′′-[1′′,3′′]dioxane]-4,4′′,6,6′′-tetrone derivatives at ambient temperature in the presence of benzoic acid as catalyst. This procedure has many advantages such as inexpensive materials, mild reaction conditions easy work-up and good yields.…”

“…Moreover, 1 H and 13 [1,3]dioxane-5,3′-quinoline-6′,5′′-[1′′,3′′]dioxane]-4,4′′,6,6′′-tetrone derivatives spectra were obtained with a Bruker DRX-400 Avance instruments (Germany) using CDCl 3 as a solvent and TMS as an internal standard at 400.2 and 100.6 MHz, respectively. Elemental analyses for C, H, and N were performed using a Heraeus CHN-O-rapid analyser (Germany).…”

“…Synthesis of structure of 1′,5′,7′,8′-tetrahydro-2′H,4′H-dispiro[[1,3]dioxane-5,3′-quinoline-6′,5′′-[1′′,3′′]dioxane]-4,4′′,6,6′′-tetrone derivatives 4a-i…”

One-pot four-component synthesis of highly substituted [1,2,4]triazolo[1,5-a]pyrimidines

“…In view of our interest in multicomponent reactions strategy and using water as a green solvent [14][15][16][17][18][19][20][21][22][23][24][25], herein we wish to report an efficient and green four-component procedure for the synthesis of a new class of [1,2,4]triazolo[1,5-a]pyrimidine-6-carboxamide derivatives 5 via a condensation reaction between an amine 1, 2,2,6-trimethyl-4H -1,3-dioxin-4-one 2, an aldehyde 3, and 3-amino-1,2,4-triazole 4 in the presence of catalytic amounts of p-toluenesulfonic acid (p-TsOH · H 2 O) as a catalyst in water (Scheme 1).…”