Synthesis of Folic Acid-Modified DOX@ZIF-8 Nanoparticles for Targeted Therapy of Liver Cancer

Abstract

The effective chemotherapy treatment for liver cancer patients remains an urgent issue due to the difficulty in precisely delivering drugs to the tumor site. The targeted delivery of drugs by nanoparticles is a promising strategy to address this problem. However, the fabrication of drug targeted delivery nanosystem still remains a major challenge. In this study, a novel folic acid-functionalized (doxorubicin, DOX) DOX@ZIF-8 nanoparticles (DOX@ZIF-8-FA) were prepared as a liver cancer-targeted drug delivery system. The delivery nanosystem exhibited a high drug loading capacity (15.7 wt%) and presented excellent drug-sustained release performances and good pH-responsive properties. Compared with free DOX and DOX@ZIF-8 nanoparticles, the DOX@ZIF-8-FA nanoparticles displayed much higher anticancer efficiency in HepG2 cells, suggesting that the folic acid-functionalized DOX@ZIF-8 nanoparticles have promising applications in targeted treatment of cancer cells.

Anti-inflammatory and antioxidant effects of nanoformulations composed of metal-organic frameworks delivering rutin and/or piperine natural agents

“…The TiMOFTS-Pip nanoformulation had the maximum TLC for Pip (17.11 ± 1.43%), and the TiMOFTS-Ru nanoformulation had the maximum for Ru (15.56 ± 1.24%). The obtained TLCs for Ru and Pip are in line with previous reports for drugs loaded to various MOFs, such as DOX (∼16 wt.%; Bi et al, 2018 ) and gentamicin (19 wt.%; Soltani et al, 2018 ). In general, both TLC and EE were significantly affected by type of MOF material.…”

“…As such, mixed release patterns are likely the result of having no burst in the first stage, with a slight increase in Ru or Pip release at the second stage. The observation of a two-stage pattern is in agreement with previous reports, including release of ibuprofen from various MOFs (Silva et al, 2016;Rojas et al, 2018;Pham et al, 2020), 5-fluorouracil from Mg-MOFs (Hu et al, 2020), caffeine from ZrMOFs , and DOX from a zeolitic imidazolate MOF (Bi et al, 2018).…”

Metal–organic frameworks encapsulated with an anticancer compound as drug delivery system: Synthesis, characterization, antioxidant, anticancer, antibacterial, and molecular docking investigation

“…The concern should be greater in the case of chemotherapeutic medications because most anticancer medicines are very toxic to fit cells and harm healthy cells lengthways with cancer cells, resulting in side properties for patients. [1,2] These problems can be solved and toxicity decreased if the meds are delivered via a carrier that delivers the drugs perfectly on request. To accomplish accurate and targeted medication delivery, we require a drug delivery system that carries pharmaceuticals to our target cells in a controlled manner without damaging healthy cells.…”

Degradation kinetic study of ZIF-8 microcrystals with and without the presence of lactic acid

“…More oen, various pHadjusted solutions based on PBS have been used to estimate the release kinetics at neutral conditions or provide a comparison at lower pH. [7][8][9][10][11][32][33][34][35][36][37][38] The choice of PBS is usually argued by its osmolarity and ion concentrations matching the human body.…”