Synthesis of ferrocene-labelled steroid derivatives via homogeneous catalytic methods

Szánti-Pintér, Eszter; Csók, Zsolt; Kollár, László; Vékey, Károly; Skoda‐Földes, Rita

doi:10.1016/j.jorganchem.2012.08.013

Cited by 10 publications

(19 citation statements)

References 26 publications

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“…Palladium (II) complexes containing P^N ligands were prepared according to the literature using PdCl 2 as precursor. Palladium complexes based on Pd (OAc) 2 were also prepared with the aim of studying these complexes as catalysts, as the use of in situ palladium acetate systems is widely known .…”

Section: Resultsmentioning

confidence: 99%

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New palladium (II) complexes containing phosphine‐nitrogen ligands and their use as catalysts in aminocarbonylation reaction

Aranda

Moya

Vega

et al. 2019

Applied Organom Chemis

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Aminocarbonylation of aryl halides, homogeneously catalysed by palladium, is an efficient method that can be employed for obtaining amides for pharmaceutical and synthetic applications. In this work, palladium (II) complexes containing P^N ligands were studied as catalysts in the aminocarbonylation of iodobenzene in the presence of diethylamine. Two types of systems were used: a palladium (II) complex formed in situ; and one prepared prior to the catalytic reaction. In general, the palladium complexes studied achieved high conversions in an average reaction time of less than 2 hr, which is less than that for the standard system (Pd (II)/PPh3) used. The pre‐synthesized complexes were faster than their in situ counterparts, as the latter require an induction time to form the Pd/P^N species. The structure and electronic properties of the ligand P^N can influence both the activity and the selectivity of the reaction, stabilizing the acyl‐palladium intermediates formed in a better manner.

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Section: Resultsmentioning

confidence: 99%

“…Catalytic experiments resumed in Table were carried out at high CO pressure with the goal to compare with previously reported works . In all entries, amide ( b ) is the favoured product.…”

Section: Effect Of the Auxiliary Ligand And Low Co Pressure In The Ammentioning

confidence: 99%

New palladium (II) complexes containing phosphine‐nitrogen ligands and their use as catalysts in aminocarbonylation reaction

Aranda

Moya

Vega

et al. 2019

Applied Organom Chemis

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“…Thus, ferrocenes and titanocenes steroid conjugates are excellent drugs and have a great future in nanochemistry and nanomedicine. Figure 6: Bioactive titanocene steroid conjugates (35)(36)(37)(38)(39)(40)(41)(42)…”

Section: Discussionmentioning

confidence: 99%

“…[35] Ferrocene containing steroid (13) was synthesized, but pharmacological activity was not studied. [36,37] Ferrocenyl cholesterol derivatives (19,20,22,23) were synthesized by different authors, however, their biological activity was not determined. [38][39][40] Ferrocenoyl of 3β,5Z,7E,22E)-9,10-secoergosta-5,7,10(19),22-tetraen-3-olate (21) showed the lowest anti-proliferative activity.…”

Section: Ferrocene Steroid Conjugatesmentioning

confidence: 99%

Ferrocene and titanocene steroid conjugates: Structures and activities – a brief review

Dembitsky

Gloriozova

Imbs

2018

Vietnam Journal of Chemistry

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The present review describes the biological activities of ferrocenes and titanocenes steroid conjugates. Ferrocenes steroid conjugates demonstrate antineoplastic and antihypercholesterolemic activity with a confidence more than 90 percent, and can be used as erythropoiesis‐stimulating agents. Titanocenes steroid conjugates show anti‐inflammatory and anti‐seborrheic activity with a confidence more than 70 percent, and can also be used as glutaconyl‐CoA decarboxylase inhibitors and/or erythropoiesis‐stimulating agents. With the computer programme PASS and based on structure–activity relationships (SAR), some additional activities are also predicted, which point towards new possible applications of these lipids. This review is devoted to synthetic lipids ferrocenes and titanocenes steroid conjugates and their biological activity, which are of great interest for medicine, as well as for pharmacologists and the pharmaceutical industry.

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“…In 2012 new ferrocene labelled steroid derivatives were obtained by Skoda-Földes et al 19 via a palladiumcatalyzed carbonylative Sonogashira coupling and a copper-catalyzed azide alkyne cycloaddition. Three steroid derivatives with a 17-ethynyl substituent (Scheme 11, 53a-55a) were chosen as model compounds to obtain new ferrocene-steroid conjugates.…”

Section: Page 206mentioning

confidence: 99%

Copper-catalyzed steroid reactions

Ibrahim‐Ouali¹,

Dumur²

2017

Arkivoc

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Synthesis of ferrocene-labelled steroid derivatives via homogeneous catalytic methods

Cited by 10 publications

References 26 publications

New palladium (II) complexes containing phosphine‐nitrogen ligands and their use as catalysts in aminocarbonylation reaction

New palladium (II) complexes containing phosphine‐nitrogen ligands and their use as catalysts in aminocarbonylation reaction

Ferrocene and titanocene steroid conjugates: Structures and activities – a brief review

Copper-catalyzed steroid reactions

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