Synthesis of far-red- and near-infrared-emitting Cu-doped InP/ZnS (core/shell) quantum dots with controlled doping steps and their surface functionalization for bioconjugation

Lim, Moo-Sup; Lee, Wonseok; Bang, Gyuhyun; Lee, Woojin; Park, Youngrong; Kwon, Yong‐Ju; Jung, Yebin; Kim, Sungjee; Bang, Jiwon

doi:10.1039/c9nr02192b

Cited by 39 publications

(48 citation statements)

References 55 publications

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“…This stems from a large disparity in a lattice constant between InP core and ZnS outer shell [21,22,23,25]. However, other doped InP QDs with Cu + [16,17,18] or Ag + ion [32] in the literature consisted of only a single shell. Although even higher PL QYs of 66 and 75% were reported from Cu- [17] and Ag-doped InP QDs [32], respectively, they commonly produced dual emissions of host excitonic plus dopant PL.…”

Section: Resultsmentioning

confidence: 99%

“…Further, III–V InP QDs are emerging visible emitters particularly for the application to display devices owing to their low-toxicity (i.e., Cd-free composition) as well as high-quality fluorescent attributes (e.g., high PL quantum yield (QY) and narrow PL bandwidth). II–VI metal chalcogenides with an ionic bonding character may be a better host for Cu doping than III–V InP with a stronger covalent bonding (i.e., weaker bond breaking ability) [16]. Nevertheless, successful Cu doping in InP host QDs, albeit limited, has been demonstrated typically by either nucleation doping [17] or the surface adsorption-lattice diffusion approach [16,18,19].…”

Section: Introductionmentioning

confidence: 99%

“…II–VI metal chalcogenides with an ionic bonding character may be a better host for Cu doping than III–V InP with a stronger covalent bonding (i.e., weaker bond breaking ability) [16]. Nevertheless, successful Cu doping in InP host QDs, albeit limited, has been demonstrated typically by either nucleation doping [17] or the surface adsorption-lattice diffusion approach [16,18,19]. Among a few reports on Cu-doped InP (InP:Cu) QDs, Mei et al claimed that dual emission in a single InP:Cu QD was obtainable from the combined PL of two competitive excitonic and Cu state-related recombinations [17].…”

Section: Introductionmentioning

confidence: 99%

“…In this context, dual emission observed in doped QDs alludes to the unwilled coexistence of undoped plus doped QDs in the ensemble. All InP:Cu QDs reported to date possessed a simple core/shell heterostructure with a single shell of either ZnSe [18] or ZnS [16,17]. From the state-of-the-art undoped InP QD systems, however, a single shelling in particular with ZnS is not an ideal scheme in securing high fluorescence, since a large lattice mismatch (ca.…”

Section: Introductionmentioning

confidence: 99%

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Emission Enhancement of Cu-Doped InP Quantum Dots through Double Shelling Scheme

Kim

Yoon

et al. 2019

Materials

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The doping of transition metal ions, such as Cu+ and Mn2+ into a quantum dot (QD) host is one of the useful strategies in tuning its photoluminescence (PL). This study reports on a two-step synthesis of Cu-doped InP QDs double-shelled with ZnSe inner shell/ZnS outer shell. As a consequence of the double shelling-associated effective surface passivation along with optimal doping concentrations, Cu-doped InP/ZnSe/ZnS (InP:Cu/ZnSe/ZnS) QDs yield single Cu dopant-related emissions with high PL quantum yields of 57–58%. This study further attempted to tune PL of Cu-doped QDs through the variation of InP core size, which was implemented by adopting different types of Zn halide used in core synthesis. As the first application of doped InP QDs as electroluminescent (EL) emitters, two representative InP:Cu/ZnSe/ZnS QDs with different Cu concentrations were then employed as active emitting layers of all-solution-processed, multilayered QD-light-emitting diodes (QLEDs) with the state-of-the-art hybrid combination of organic hole transport layer plus inorganic electron transport layers. The EL performances, such as luminance and efficiencies of the resulting QLEDs with different Cu doping concentrations, were compared and discussed.

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Emission Enhancement of Cu-Doped InP Quantum Dots through Double Shelling Scheme

Kim

Yoon

et al. 2019

Materials

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“…However, their cytotoxicity, mainly due to the liberation of free ions, is now well documented 19,20 . A new generation of far-red emitting QDs has been recently described to efficiently label breast cancer cell line in culture without cytotoxicity 21 . Primary cell or in vivo imaging and TPEF-microscopy applications have not been reported yet.…”

mentioning

confidence: 99%

Multiscale fluorescent tracking of immune cells in the liver with a highly biocompatible far-red emitting polymer probe

Daniel

Dubreil

Fleurisson

et al. 2020

Sci Rep

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The development of innovative immune cell therapies relies on efficient cell tracking strategies. For this, multiscale fluorescence-based analyses of transferred cells into the host with complementary techniques, including flow cytometry for high-throughput cell analysis and two-photon microscopy for deep tissue imaging would be highly beneficial. Ideally, cells should be labelled with a single fluorescent probe combining all the properties required for these different techniques. Due to the intrinsic autofluorescence of most tissues and especially the liver, far-red emission is also an important asset. However, the development of far-red emitting probes suitable for two-photon microscopy and compatible with clearing methods to track labelled immune cells in thick samples, remains challenging. A newly-designed water-soluble far-red emitting polymer probe, 19K-6H, with a large Stokes shift, was thus evaluated for the tracking of primary immune CD8 T cells. These cells, prepared from mouse spleen, were efficiently labelled with the 19K-6H probe, which was internalized via endocytosis and was highly biocompatible at concentrations up to 20 μM. Labelled primary CD8 T cells were detectable in culture by both confocal and two-photon microscopy as well as flow cytometry, even after 3 days of active proliferation. Finally, 19K-6H-labelled primary CD8 T cells were injected to mice in a classical model of immune mediated hepatitis. The efficient tracking of the transferred cells in the liver by flow cytometry (on purified non-parenchymal cells) and by two-photon microscopy on 800 μm thick cleared sections, demonstrated the versatility of the 19K-6H probe.

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A First Wide‐Open LDH Structure Hosting InP/ZnS QDs: A New Route Toward Efficient and Photostable Red‐Emitting Phosphor

et al. 2021

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The architecture of Zn‐Al layered double hydroxides (LDHs), organo‐modified with bola‐amphiphiles molecules, is matching its interlayer space to the size of narrow‐band red‐emitting InP/ZnS core–shell quantum dots (QDs) to form original high‐performance functional organic–inorganic QD‐bola‐LDH hybrids. The success of size‐matching interlayer space (SMIS) approach is confirmed by X‐ray diffraction, small angle X‐ray scattering (SAXS), TEM, STEM‐HAADF, and photoluminescence investigations. The QD‐Bola‐LDH hybrid exhibits a photoluminescence quantum yield three times higher than that of pristine InP/ZnS QDs and provides an easy dispersion into silicone‐based resins, what makes the SMIS approach a change of paradigm compared to intercalation chemistry using common host structures. Moreover, this novel hybrid presents low QD–QD energy transfer comparable to that obtained for QDs in suspension. Composite silicone films incorporating InP/ZnS (0.27 wt%) QD‐bola‐LDH hybrids further show remarkable improved photostability relative to pristine QDs. An LED overlay consisting of a blue LED chip and silicone films loaded with QD‐bola‐LDH hybrids and YAG:Ce phosphors exhibits a color rendering index close to 94.

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Synthesis of far-red- and near-infrared-emitting Cu-doped InP/ZnS (core/shell) quantum dots with controlled doping steps and their surface functionalization for bioconjugation

Abstract: Non-cadmium-based highly bright and stable far-red- and near-infrared (NIR)-emitting Cu-doped InP/ZnS (core/shell) quantum dots were synthesized with precisely controlled doping steps and were employed for bioimaging probes.

Cited by 39 publications

References 55 publications

Emission Enhancement of Cu-Doped InP Quantum Dots through Double Shelling Scheme

Emission Enhancement of Cu-Doped InP Quantum Dots through Double Shelling Scheme

Multiscale fluorescent tracking of immune cells in the liver with a highly biocompatible far-red emitting polymer probe

A First Wide‐Open LDH Structure Hosting InP/ZnS QDs: A New Route Toward Efficient and Photostable Red‐Emitting Phosphor

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