Synthesis of exchange coupled nanoflowers for efficient magnetic hyperthermia

Shaw, S.K.; Biswas, Arpan; Gangwar, Anshu; Maiti, Pralay; Prajapat, C.L.; Meena, Sher Singh; Prasad, N.K.

doi:10.1016/j.jmmm.2019.04.056

Cited by 33 publications

(15 citation statements)

References 46 publications

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“…For example, cubic nanoparticles have been found to be preferable for contrast agents compared to spherical particles (with similar volume), 13,14 While angular "nanoflower" shaped MNPs have been found to have a higher hyperthermic heating compared to spherical MNPs. 15,16 This is thought to be due to the physical effect of the edges. 15,16 As such, demand for non-spherical faceted MNPs in the biomedical industry is on the rise with synthetic control over the size, shape, and crystal quality of particles being crucial.…”

Section: Introductionmentioning

confidence: 99%

Ethylenediamine series as additives to control the morphology of magnetite nanoparticles

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Section: Introductionmentioning

confidence: 99%

Ethylenediamine series as additives to control the morphology of magnetite nanoparticles

et al. 2021

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“…Hyperthermia can destroy the cancer cells with minimal influence on the healthy tissues, so it could potentially be used for localized, scarless, and economical treatments with few side effects. The efficacy of the hyperthermia process depends on many factors, such as properties of the magnetic nanoparticles, the magnitude of the applied AC magnetic field ( H ), and its frequency ( f ) and duration ( t ) of actuation [8,9]. The magnitude and frequency of the applied AC magnetic field must remain within safe limits to prevent unwanted side effects.…”

Section: Introductionmentioning

confidence: 99%

Synthesis of Magnetic Ferrite Nanoparticles with High Hyperthermia Performance via a Controlled Co-Precipitation Method

et al. 2019

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Magnetic nanoparticles (MNPs) that exhibit high specific loss power (SLP) at lower metal content are highly desirable for hyperthermia applications. The conventional co-precipitation process has been widely employed for the synthesis of magnetic nanoparticles. However, their hyperthermia performance is often insufficient, which is considered as the main challenge to the development of practicable cancer treatments. In particular, ferrite MNPs have unique properties, such as a strong magnetocrystalline anisotropy, high coercivity, and moderate saturation magnetization, however their hyperthermia performance needs to be further improved. In this study, cobalt ferrite (CoFe2O4) and zinc cobalt ferrite nanoparticles (ZnCoFe2O4) were prepared to achieve high SLP values by modifying the conventional co-precipitation method. Our modified method, which allows for precursor material compositions (molar ratio of Fe+3:Fe+2:Co+2/Zn+2 of 3:2:1), is a simple, environmentally friendly, and low temperature process carried out in air at a maximum temperature of 60 °C, without the need for oxidizing or coating agents. The particles produced were characterized using multiple techniques, such as X-ray diffraction (XRD), dynamic light scattering (DLS), transmission electron microscopy (TEM), ultraviolet-visible spectroscopy (UV–Vis spectroscopy), and a vibrating sample magnetometer (VSM). SLP values of the prepared nanoparticles were carefully evaluated as a function of time, magnetic field strength (30, 40, and 50 kA m−1), and the viscosity of the medium (water and glycerol), and compared to commercial magnetic nanoparticle materials under the same conditions. The cytotoxicity of the prepared nanoparticles by in vitro culture with NIH-3T3 fibroblasts exhibited good cytocompatibility up to 0.5 mg/mL. The safety limit of magnetic field parameters for SLP was tested. It did not exceed the 5 × 109 Am−1 s−1 threshold. A saturation temperature of 45 °C could be achieved. These nanoparticles, with minimal metal content, can ideally be used for in vivo hyperthermia applications, such as cancer treatments.

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“…151 Large relaxivity and SAR (up to 1210 W g À1 for H ¼ 236 Oe and f ¼ 630 kHz) make this system suitable for a theranostic (therapy + diagnostic) platform that combines both hyperthermia and MRI. 151 Apart from the core/shell structure, other different exchangecoupled arrangements of HNPs have also been investigated for magnetic hyperthermia, such as nanoowers consisting of g-Fe 2 O 3 magnetic grains grown over the surface of MnFe 2 O 4 core, 152 or Fe 3 O 4 MNPs with embedded FeO nanoclusters. 153 In this regard, there is still ongoing research on several possible hetero-structures and assemblies that can allow one to tune of the magnetic properties of the MNPs in order to enhance their biomedical performance.…”

Section: A Exchange-couplingmentioning

confidence: 99%

Hybrid magnetic nanoparticles as efficient nanoheaters in biomedical applications

et al. 2021

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Synthesis of exchange coupled nanoflowers for efficient magnetic hyperthermia

Cited by 33 publications

References 46 publications

Ethylenediamine series as additives to control the morphology of magnetite nanoparticles

Ethylenediamine series as additives to control the morphology of magnetite nanoparticles

Synthesis of Magnetic Ferrite Nanoparticles with High Hyperthermia Performance via a Controlled Co-Precipitation Method

Hybrid magnetic nanoparticles as efficient nanoheaters in biomedical applications

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