Synthesis of Enantiomeric α-Cephalins^1,2

Metabolism and functions of phosphatidylserine

“…PS was first identified as a distinct entity of brain ''cephalin'' by Folch in 1941 [1]. In 1952, Baer and Maurukas [2] elucidated the chemical structure of PS which was subsequently confirmed by chemical synthesis. Mammalian cell membranes contain more than 1000 different types of phospholipid molecules with much of the diversity originating from the large variety of fatty acyl chains that are esterified to the sn-1 and sn-2 positions of the glycerol backbone of the phospholipid.…”

Synthesis of phosphoglycerides

“…Baer et al (45), drawing upon their experience with PCs, prepared PE in much the same fashion. The amino function in ethanolamine phosphatidyl choline (36).…”

Contribution à l'étude de quelques esters phosphoriques d'aminoéthanol

“…C'est cette méthode qui a été employée pour la synthèse de très nombreux produits, y compris les lécithines et les céphalines (BAER [47,48,49,50,51,52,53,54,55,56,57,58], MAURUKAS [59], RosE [60] [ 14] ) .…”

“…Ils préparent le diéthylphosphate de N-diéthyla-minoéthanol (III, R = R' = R" = C2H5) (1). Ils [46], BAILLY [162,163], CAVALIER [164], , DRUSHEL [165, , IÛ6~, , GULLAND ~IÛÎ~, , LOSSEN [168], , PLIM-MER [94] [54,169], BADDILEY [170], BAER [50,51,55], CALDERON [171,172], LARDY [173], LORA TAMAYO [174], MAURUKAS [59] [ 177] . Le N-diméthylaminoéthanol n'a pas réagi à froid sur ~l'~éthylpo~lypyro~phosphate (177 ) .…”