Abstract:Benzofurans are everywhere in nature and they have been extensively
studied by medicinal chemists over the years because of their chemotherapeutic
and physiological properties. Herein, we describe a strategy that can be used
to access elaborate benzo-2-carboxamide derivatives, which involves a synthetic
sequence of 8-aminoquinoline directed C–H arylations followed by transamidations.
For the directed C–H arylations, Pd catalysis was used to install a wide range
of aryl and heteroaryl substituents at the C3 pos… Show more
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