Synthesis of Diorganylphosphine Oxides Bearing Hetarylalkyl Moieties and Study of Their Antimicrobial Activities

Abstract

Tertiary phosphine oxides have been synthesized by the reaction of secondary phosphine oxides with diverse hetarylmethylchlorides (pyridines, imidazoles, pyrazole) in the superbasic systems CsF/NaOH/DMF/4 Å MS or NaOH/DMSO/4 Å MS at 23-25 °C. It is found that a tertiary phosphine oxide bearing the imidazole fragment possess the pronounced antimicrobial activity.