Synthesis of dimethyl carbonate and propylene glycol in a membrane-assisted reactive distillation process: Pilot-scale experiments, modeling and process analysis

Holtbruegge, Johannes; Wierschem, Matthias; Lutze, Philip

doi:10.1016/j.cep.2014.01.008

Cited by 37 publications

(23 citation statements)

References 46 publications

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“…The experiments do not exhibit a temperature change downwards from the feed location of the heavy boiler PE, which should increase the boiling temperature and therefore the vapor temperature, accordingly. Holtbruegge et al 31 justified this deviation with non-adiabatic operation of the real column, while adiabatic operation is assumed in the model. While the accuracy of the VLE description could not be validated for all of the binary mixtures due to the absence of dedicated experimental data, at least the reboiler temperature and composition exhibit a good fit, justified by the agreement between experiment and simulation.…”

Section: Experimental Results and Validationmentioning

confidence: 99%

Section: Investigation Of Enzymatic Reactive Distillationmentioning

confidence: 99%

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Model validation for enzymatic reactive distillation to produce chiral compounds

Wierschem

Langen

Lins

et al. 2017

J of Chemical Tech & Biotech

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BACKGROUND Enzymatic reactive distillation (ERD) is a biocatalyzed process, in which enzymes are immobilized in catalytic packing. The combination of enzymatic reaction and thermal separation helps to overcome chemical reaction and phase equilibrium limitations. Processing of chiral molecules, in particular, can benefit from ERD application, which might lead to more eco‐efficient processing of these valuable chemicals. Therefore an integrated approach to evaluate this technology is followed. RESULTS To evaluate ERD the transesterification of racemic (R/S)‐1‐phenylethanol (RPE/SPE) to (R)‐phenylethyl acetate (PEA) catalyzed by Candida antarctica lipase B (EC: 3.1.1.3) is investigated with regard to kinetics and physical property data, which provide a basis for the modeling of an ERD process. Furthermore, ERD experiments show a selective conversion of RPE to PEA, which is predicted by the established ERD model with high accuracy. CONCLUSION The ERD experiments demonstrate the feasibility of chiral processing for the transesterification by means of ERD and a validated ERD model is developed, allowing for a conceptual evaluation of ERD. This provides the basis for a future comparison of ERD with benchmark processes that will reveal the economic potential of ERD processes. © 2017 Society of Chemical Industry

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Section: Experimental Results and Validationmentioning

confidence: 99%

Section: Investigation Of Enzymatic Reactive Distillationmentioning

confidence: 99%

Model validation for enzymatic reactive distillation to produce chiral compounds

Wierschem

Langen

Lins

et al. 2017

J of Chemical Tech & Biotech

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“…PI options are, therefore, oftentimes only identified in subsequent debottlenecking studies of existing processes rather than in the design of new processes , . In order to enable the consideration of PI during process synthesis, either an extended portfolio of equipment options needs to be considered , or process synthesis needs to be performed on a lower, more abstract level of aggregation. For the latter, a number of modeling environments have been proposed by several authors , which reach down to the consideration of single phenomena.…”

Section: Introductionmentioning

confidence: 99%

Analysis of TBA‐Based ETBE Production by Means of an Optimization‐Based Process‐Synthesis Approach

Kuhlmann

Möller

Skiborowski

2018

Chemie Ingenieur Technik

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The current article presents the extension of a recently developed optimization‐based approach to process synthesis for process intensification. It generates phenomena‐based flowsheet options using superstructure optimization and provides a dedicated translation into equipment‐based flowsheets. The considered case‐study illustrates the application of the method for the analysis of ethyl tert‐butyl ether production, based on the conversion of tert‐butyl alcohol, under consideration of variable configurations of a rector network and a newly introduced pervaporation‐based membrane‐reactor block.

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“…Intensified operations provide innovative ways for performing reaction, reaction plus separation or separation. Spinning disc reactors [25,28], reactive distillation [1] and membrane-based operations [13] are examples of intensified operations. Membrane-based operations are good candidates for inclusion in the process flowsheet because of their efficient task-performance.…”

Section: Introductionmentioning

confidence: 99%

A process synthesis-intensification framework for the development of sustainable membrane-based operations

Babi

Lutze

Woodley

et al. 2014

Chemical Engineering and Processing: Process Intensification

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Synthesis of dimethyl carbonate and propylene glycol in a membrane-assisted reactive distillation process: Pilot-scale experiments, modeling and process analysis

Cited by 37 publications

References 46 publications

Model validation for enzymatic reactive distillation to produce chiral compounds

Model validation for enzymatic reactive distillation to produce chiral compounds

Analysis of TBA‐Based ETBE Production by Means of an Optimization‐Based Process‐Synthesis Approach

A process synthesis-intensification framework for the development of sustainable membrane-based operations

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