Synthesis of diethylamino-curcumin mimics with substituted triazolyl groups and their sensitization effect of TRAIL against brain cancer cells

Chalcone Scaffold in Anticancer Armamentarium: A Molecular Insight

“…Against human CRT-MG astroglioma cells by using the lactate dehydrogenase (LDH) release assay, it was found that compounds 39a and 39b with TRAIL (25 ng/mL) showed good cytotoxicity. 2-Ethylamino and substituted triazole groups are promising templates in the backbone of chalcone to develop TRAIL sensitizers as anticancer agents [ 45 ].…”

Sensitizing nanoparticle based platinum(IV) drugs by curcumin for better chemotherapy

“…Curcumin (diferuloylmethane) is a phytochemical that has a wide range of therapeutic activities and has potent antiproliferative effects against a variety of tumors in vitro [1][2][3]. Curcumin has been found to interact with a wide variety of cell signaling proteins, down-regulated transcription factors, and multidrug resistance (MDR) proteins [4][5][6][7][8].…”

TRAIL and curcumin codelivery nanoparticles enhance TRAIL-induced apoptosis through upregulation of death receptors

“…Combination therapy is one of the most frequently used strategies to overcome above-mentioned obstacles, which has been proved to be more effective than monotherapy by achieving synergistic effects and reducing toxicity. TRAIL was found to have synergistic interaction with other drugs like Curcumin (Cur) (Jung et al., 2005 , 2006 ; Yang et al., 2012 ; Ahn et al., 2014 ; An et al., 2014 ). Cur is a natural yellow pigment purified from the rhizome of the plant Curcuma longa , which has exhibited a wide range of pharmacological activities like antimicrobial, anti-inflammatory and anticancer without obvious side effects (Anand et al., 2008 ; Naksuriya et al., 2014 ).…”