Synthesis of dibenzopiperidinoaza-14-crown-4 ethers and their one-step conversion into dibenzo-16-crown-3

Dimethyl 2-[23-oxo-22,24-diphenyl-8,11,14-trioxa-25-azatetracyclo[19.3.1.02,7.015,20]pentacosa-2,4,6,15(20),16,18-hexaen-25-yl]but-2-enedioate

“…For related compounds, see: Levov et al (2006Levov et al ( , 2008; Anh et al (2008); Hieu et al (2011); Khieu et al (2011). Table 1 Hydrogen-bond geometry (Å , ).…”

“…Recently we have developed the effective methods of synthesis of azacrown ethers containing piperidine (Levov et al, 2006Anh et al, 2008), perhydropyrimidine (Hieu et al, 2011) and perhydrotriazine subunits (Khieu et al, 2011).…”

Novel Podands Containing N-Arylthiosemicarbazide Moiety

“…[1,2,[5][6][7] Recently, researches on the antibacterial and cytotoxicity, anticancer (in vitro) of podands containing thiosemicarbazides moiety has been reported. [8,9] Studying was carried out on 60 types Novel Podands Containing N-Arylthiosemicarbazide Moiety of cancer cells from malignant tumors at different tissues: lung cell, breast cell… [9] In addition, this type of podand is also an important part in structures of azacrown ether compounds [10][11][12][13][14][15][16][17][18][19][20][21] and other crownophane [22] or polycyclic crownophane [23] which are studying hardly by scientists in recent years. Therefore, the development of synthetic methods of compounds containing "privilege" fragments including polyether and N-arylthiosemicarbazide derivatives as well as exploration of bioactivities of these podands are interesting targets.…”

Synthesis and Molecular Structure of Dibenzo [4-(α-Thienyl- and α-Pyrrolyl)pyrido]aza-14-crown-4 Ethers

“…[1,2] Recently, the synthesis of azacrown ethers bearing fused nitrogen-containing heterocyclic rings has drawn the interest of scientists because such combination can enhance the properties of both components, including biological activity. [2][3][4][5][6][7] By using domino reactions in the synthesis of azacrown ethers, we had earlier obtained dibenzo[(γ-phenyl)pyrido)]aza-14-crown-4 ether from benzaldehyde, 1,4-bis(2-acetylphenoxy)-3-oxapentane (1) and ammonium acetate. In addition we had established that such compounds containing γ-phenylpyridine ring exhibited cytotoxicity to several cancer cell lines: Hepatocellular carcinoma (Hep-G2); Rhabdosarcoma (RD), Human Uterine (FL); Human Breast adenocarcinoma (MCF7).…”