Synthesis of Diarylamines via Nitrosonium-Initiated C–N Bond Formation
Pin-Hsien Chen,
Shu-Jung Hsu,
Cheng-Chun Chen
et al.
Abstract:Electron-rich diarylamines, exemplified by anisole-derived
amines,
play pivotal roles in process chemistry, pharmaceuticals, and materials.
In this study, homo-diarylamines were synthesized directly from the
C–H activation of electron-rich arenes by sodium nitrate/trifluoroacetic
acid and the successive treatment of iron powder. Mechanistic investigations
reveal that nitrosoarene serves as the reaction intermediate, and
the formation of the second C–N bond between the resulting
nitrosoarene and electron-rich a… Show more
Set email alert for when this publication receives citations?
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.