Synthesis of deuterium‐labelled paclitaxel and its hydroxyl metabolite

Abstract

bÃThis paper describes the synthesis of deuterium-labelled paclitaxel and its hydroxyl metabolite. Paclitaxel labelled with 2 H was obtained in four steps using the commercially available [ 2 H 5 ]benzoic chloride as the stable labelled reagent with a 40% overall yield. The hydroxyl metabolite labelled with 2 H was prepared starting from deuterium-labelled paclitaxel in six steps with a 42% overall yield based on unrecovered starting material.