Synthesis of derivatives of <em>β</em>-sitosterol and evaluation of their anti-bacterial activity

Abstract

Highlights• β-Sitosterol was isolated from ripen fruits of Avocado with a relatively good yield.• Four derivatives were synthesized and C6 hydroxy β-sitosterol was reported for the first time.• The anti-bacterial activity was reduced for derivatives with increasing lipophilicity.• Hydroxyl groups at C3 and C6 are significant towards the antibacterial activity.