Synthesis of dendrimeric N-glyoxylamide peptide mimics

An Expedient Synthesis of Pyrrolo[3,2,1‐ij]quinoline‐1,2‐diones via Intramolecular Friedel–Crafts Cyclization Protocol

“…The decomposition was accelerated at elevated temperature (120 °C) in PPA presumably by the cleavage of the amide bond of the isatin moiety. The 6,5,6‐tricyclic ring system of 4a was somewhat strained, 2a,c thus an amide bond cleavage of the isatin moiety could proceed under the acidic conditions . The reaction of 3a in the presence of H 2 SO 4 (5.0 equiv) in 1,2‐dichloroethane (reflux, 2 h) was ineffective.…”

Short Cationic Peptidomimetic Antimicrobials

“…Kumar et al have developed peptidomimetics based on glyoxamide and carboxamide scaffolds. Mono- and bis-glyoxamide derivatives and dendrimeric peptide mimics were synthesised by a simple and efficient ring-opening reaction of N -acylisatins with a range of amino acids [91,92]. However, the compounds’ antibacterial activity was not reported.…”

Recent developments and applications of bioinspired dendritic polymers

“…Featured by the controllable three-dimensional nanostructures and monodisperse properties, dendritic polymers are usually regarded as ideal analogues of some proteins and peptides, such as amelogenin, 57 dentine phosphophoryn, 58 mussel foot proteins, 59 polypeptide, 60 silaffin, 61 ferritins, 62 glycoprotein 63 and molecular chaperone. 64 Under the control of a series of biomolecules, inorganic minerals are formed programmatically in a biological environment, which is called as biomineralization.…”

“…To date, a number of artificial peptide mimics have been reported. 60,110,111 For example, Huang et al 110 prepared a peptidomimetic, poly(amidoamine)-poly(benzyl L-glutamate) amphiphiles with adjustable sizes. These self-assembled aggregates were stable in aqueous solution for 64 days at room temperature and 16 days at 37 °C which showed potential applications as a drug/gene carrier.…”