Synthesis of Dendrimer with PEG Core by Click Chemistry

Abstract

Efficient stitching methods for the synthesis of Fréchet-type dendrimers with linear PEG units at a core were elaborated. The synthetic strategy involved an inexpensive 1,3-dipolar cycloaddition reaction between an alkyne and an azide in the presence of Cu(I) species which is known as the best example of click chemistry. The linear core building blocks, two diazido-PEG units, were chosen to serve as the azide functionalities for dendrimer growth via click reactions with the alkyne-dendrons. These two building blocks were employed together with the alkyne-functionalized Fréchet-type dendrons in a convergent strategy to synthesize two kinds of Fréchet-type dendrimers with different linear core units.