Synthesis of cyclodextrin‐based temperature/enzyme‐responsive nanoparticles and application in antitumor drug delivery

Teng, Jinkui; Yue, Lulu; Li, Bi-Lian; Yang, Jianmei; Yang, Cuiting; Yang, Tong; Zhi, Xiangye; Liu, Xiaoqing; Zhao, Yan; Zhang, Jin

doi:10.1016/j.molstruc.2022.134596

Journal of Molecular Structure

2023

DOI: 10.1016/j.molstruc.2022.134596

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Synthesis of cyclodextrin‐based temperature/enzyme‐responsive nanoparticles and application in antitumor drug delivery

Jinkui Teng

Lulu Yue²,

Bi-Lian Li³

et al.

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Cited by 8 publications

References 38 publications

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Facile Fabrication of Dual‐Activatable Gastrointestinal‐Based Nanocarriers for Safe Delivery and Controlled Release of Methotrexate

Chen,

Nie,

Zhu

et al. 2023

ChemPlusChem

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Colon cancer is emerging as one of the most common cancers worldwide, ranking in the top three in morbidity and mortality. Oral methotrexate (MTX) has been employed as a first‐line treatment for various cancers, such as colon, breast, and lung cancer. However, the complexity and particularity of the gastrointestinal microenvironment and the limitations of MTX itself, including severe adverse effects and instability, are the main obstacles to the safe delivery of MTX to colon tumor sites. Herein, an innovative oral administrated anticancer therapeutic MTX@Am7CD/SDS NPs equipped with both pH and temperature sensitivity, which could effectively prevent MTX@Am7CD/SDS NPs from being degraded in the acidic environment mimicking the stomach and small intestine, thus harboring the potential to accumulate at the site of colon lesions and further release intestinal drug under mild conditions. In cellular assays, compared with free MTX, MTX@Am7CD/SDS NPs showed a favorable tumor inhibition effect on three tumor cell lines, as well as excellent cell uptake and apoptosis‐inducing effect on SW480 cells. Therefore, this work provides a feasible solution for the safe use of MTX in the treatment of colon cancer and even other intestinal diseases.

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Facile Fabrication of Dual‐Activatable Gastrointestinal‐Based Nanocarriers for Safe Delivery and Controlled Release of Methotrexate

Chen,

Nie,

Zhu

et al. 2023

ChemPlusChem

Self Cite

View full text Add to dashboard Cite

show abstract

Synthesis of acid-activated reversible conversion supramolecular nanoplatform: application in drug delivery and anti-tumor activity

Yang,

Chen,

Teng

et al. 2023

Macromol. Res.

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Enzyme-activated binary assembly for targeted, controlled delivery of anti-liver cancer compounds

Wang,

Chen,

Chen

et al. 2024

Carbohydrate Research

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Synthesis of cyclodextrin‐based temperature/enzyme‐responsive nanoparticles and application in antitumor drug delivery

Cited by 8 publications

References 38 publications

Facile Fabrication of Dual‐Activatable Gastrointestinal‐Based Nanocarriers for Safe Delivery and Controlled Release of Methotrexate

Facile Fabrication of Dual‐Activatable Gastrointestinal‐Based Nanocarriers for Safe Delivery and Controlled Release of Methotrexate

Synthesis of acid-activated reversible conversion supramolecular nanoplatform: application in drug delivery and anti-tumor activity

Enzyme-activated binary assembly for targeted, controlled delivery of anti-liver cancer compounds

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