Synthesis of cyanoethyl konjac glucomannan and its liquid crystalline behavior in an ionic liquid

Shen, Chunhui; Li, Wei; Zhang, Ling; Wan, Chengpeng; Gao, Shanjun

doi:10.1007/s10965-011-9758-4

Cited by 11 publications

(3 citation statements)

References 41 publications

(41 reference statements)

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“…KGM hydrolysate was reported to have prebiotic potential for beneficial gut microbiota [153,154]. KGM is a water soluble polysaccharide because of hydrogen bonding in its structure [155,156]. The stronger the hydrogen bonding between their molecules, the harder for it to dissolve in water.…”

Section: Medical Potential Of Mannans As a Drug Nanocarrier Systemsmentioning

confidence: 99%

Mannan as a Promising Bioactive Material for Drug Nanocarrier Systems

Yıldız¹,

Öner²

2014

Application of Nanotechnology in Drug Delivery

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Section: Medical Potential Of Mannans As a Drug Nanocarrier Systemsmentioning

confidence: 99%

Mannan as a Promising Bioactive Material for Drug Nanocarrier Systems

Yıldız¹,

Öner²

2014

Application of Nanotechnology in Drug Delivery

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“…Konjac glucomannan (KGM), as a high-molecular-weight polysaccharide, has special physical characteristics such as moisture retentivity, thickening, and gelling properties [ 1 ] and bears so many hydroxyl groups that various chemical modifications can be realized on KGM molecular chains [ 2 , 3 , 4 , 5 , 6 ]. KGM microspheres based on KGM powder have great application prospects in the fields of separation and purification [ 7 ], cell culture [ 8 ], enzyme and cell immobilization [ 9 ], drug delivery [ 10 ] and controlled release [ 11 ].…”

Section: Introductionmentioning

confidence: 99%

Improved Stability of Emulsions in Preparation of Uniform Small-Sized Konjac Glucomanna (KGM) Microspheres with Epoxy-Based Polymer Membrane by Premix Membrane Emulsification

Zhou

et al. 2016

Polymers

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Uniform small-sized (<10 µm) Konjac glucomanna (KGM) microspheres have great application prospects in bio-separation, drug delivery and controlled release. Premix membrane emulsification is an effective method to prepare uniform small-sized KGM microspheres. However, since KGM solution bears strong alkalinity, it requires the membrane to have a hydrophobic surface resistant to alkali. In this study, uniform small-sized KGM microspheres were prepared with epoxy-based polymer membrane (EP) we developed by premix membrane emulsification. It was found that emulsion coalescence and flocculation occurred frequently due to the high interface energy and sedimentation velocity of KGM emulsions. Emulsion stability had a significant influence on the uniformity and dispersity of the final KGM microspheres. To improve the stability of the emulsions, the effects of the concentration of the emulsifier, the viscosity of the KGM solution, the oil phase composition and the feeding method of epoxy chloropropane (EC) on the preparation results were studied. Under optimal preparation conditions (emulsifier 5 wt % PO-5s, KGM III (145.6 mPa¨s), weight ratio of liquid paraffin (LP) to petroleum ether (PE) 11:1), uniform and stable KGM emulsions (d = 7.47 µm, CV = 15.35%) were obtained and crosslinked without emulsion-instable phenomena.

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“…The intrinsic viscosity of native KGM was found to be 1320 mL/g, among the highest of the polysaccharides [9]. The solubility of KGM in water is very poor even though it is a hydrophilic molecule; this feature has been markedly limited the applications of KGM [10,11]. A number of chemical and biologic modifications of KGM were introduced to obtain derivatives with improved solubility properties and/or enhanced capacity to interact with other polymers [11][12][13][14].…”

Section: Introductionmentioning

confidence: 99%

Preparation of mid-to-high molecular weight konjac glucomannan (MHKGM) using controllable enzyme-catalyzed degradation and investigation of MHKGM properties

et al. 2012

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Mid-to-high molecular weight konjac glucomannan (MHKGM) powders with different molecular weights were prepared and purified from their enzymatic hydrolysis solutions. MHKGM powder yield was optimized with respect to substrate concentration, urea concentration, the number of alcohol washings, and drying temperature. Properties of MHKGM powder were characterized by SEC, FTIR, UV, XRD, rheological, and thermal analysis techniques. The results showed that under the correct conditions a high productive yield of MHKGM can be obtained. MHKGMs have the same chemical structure as that of native KGM, but their weight average molecular weight (M w ), molecular weight distribution index (M w /M n ), radius of gyration (R g ), solution optical clarity, rheological properties, and other physical properties such as water solubility are very different from those of native KGM. This study provides useful a reference for making MHKGM powder with varying molecular weight and the potential applications of KGM such as healthy food additives.

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Synthesis of cyanoethyl konjac glucomannan and its liquid crystalline behavior in an ionic liquid

Cited by 11 publications

References 41 publications

Mannan as a Promising Bioactive Material for Drug Nanocarrier Systems

Mannan as a Promising Bioactive Material for Drug Nanocarrier Systems

Improved Stability of Emulsions in Preparation of Uniform Small-Sized Konjac Glucomanna (KGM) Microspheres with Epoxy-Based Polymer Membrane by Premix Membrane Emulsification

Preparation of mid-to-high molecular weight konjac glucomannan (MHKGM) using controllable enzyme-catalyzed degradation and investigation of MHKGM properties

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