Synthesis of curcumin-functionalized gold nanoparticles and cytotoxicity studies in human prostate cancer cell line

Nambiar, Shruti; Osei, Ernest; Fleck, Andre; Darko, Johnson; Mutsaers, Anthony J.; Wettig, Shawn D.

doi:10.1007/s13204-018-0728-6

Cited by 48 publications

(30 citation statements)

References 27 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The synthesis protocols for EGCG-AuNP and Curc-AuNP were adapted from a protocol by Nambiar et al [22]. The first step required solubilizing the polyphenol compound, which was accomplished by adding 10 mM NaOH to a vial containing EGCG or curcumin powder to form a 1 mM solution.…”

Section: Methodsmentioning

confidence: 99%

Biodistribution and Physiologically-Based Pharmacokinetic Modeling of Gold Nanoparticles in Mice with Interspecies Extrapolation

et al. 2019

Self Cite

View full text Add to dashboard Cite

Gold nanoparticles (AuNPs) are a focus of growing medical research applications due to their unique chemical, electrical and optical properties. Because of uncertain toxicity, “green” synthesis methods are emerging, using plant extracts to improve biological and environmental compatibility. Here we explore the biodistribution of green AuNPs in mice and prepare a physiologically-based pharmacokinetic (PBPK) model to guide interspecies extrapolation. Monodisperse AuNPs were synthesized and capped with epigallocatechin gallate (EGCG) and curcumin. 64 CD-1 mice received the AuNPs by intraperitoneal injection. To assess biodistribution, groups of six mice were sacrificed at 1, 7, 14, 28 and 56 days, and their organs were analyzed for gold content using inductively coupled plasma mass spectrometry (ICP-MS). A physiologically-based pharmacokinetic (PBPK) model was developed to describe the biodistribution data in mice. To assess the potential for interspecies extrapolation, organism-specific parameters in the model were adapted to represent rats, and the rat PBPK model was subsequently evaluated with PK data for citrate-capped AuNPs from literature. The liver and spleen displayed strong uptake, and the PBPK model suggested that extravasation and phagocytosis were key drivers. Organ predictions following interspecies extrapolation were successful for rats receiving citrate-capped AuNPs. This work lays the foundation for the pre-clinical extrapolation of the pharmacokinetics of AuNPs from mice to larger species.

show abstract

Section: Methodsmentioning

confidence: 99%

Biodistribution and Physiologically-Based Pharmacokinetic Modeling of Gold Nanoparticles in Mice with Interspecies Extrapolation

et al. 2019

Self Cite

View full text Add to dashboard Cite

show abstract

“…Gold nanoparticles have novel optical and catalytic properties that are non-toxic and biocompatible and drawn significant interest in a variety of applications. In recent years, gold nanoparticles synthesized with plant extracts widely used for the biomedical area (Nambiar et al, 2018). Colloidal stability of these particles keeps the physicochemical properties unchanging.…”

Section: Wound Healing and Colorectal Cancermentioning

confidence: 99%

“…The study conducted using curcumin-encapsulated chitosan-graft-poly(N-vinyl caprolactam) nanoparticles containing gold nanoparticles (Au-CRC-TRC-NPs) showed targeted delivery of drug and apoptosis to colon cancer cells (Rejinold et al, 2015). In another research, Nambiar et al synthesized curcumin gold nanoparticles (cur-AuNPs) using cell-culture medium supplemented with or without fetal bovine serum (FBS) and confirmed their anticancer effects in human prostate cancer cells (Nambiar et al, 2018). The gold nanoparticles with curcumin (CWAuNPs) examined for its effects on in vitro renal cancer cells.…”

Section: Wound Healing and Colorectal Cancermentioning

confidence: 99%

Nanocurcumin: A Promising Candidate for Therapeutic Applications

2020

View full text Add to dashboard Cite

“…However, proteins from the growth serum of cells can absorb to both cationic and anionic particles, forming a protein corona which has the potential to alter their charge and thus minimizes attractive forces [84, 85]. The effect of proteins adsorbing onto AuNPs has been observed through numerous studies including absorbtion on curcumin-functionalized AuNP where the uptake in human prostate cancer cells was decreased when curcumin-AuNP were in the presence of serum containing media compared to serum-free media [86].…”

Section: Uptake and Interaction With Cellsmentioning

confidence: 99%

Biomedical applications of polyelectrolyte coated spherical gold nanoparticles

Fuller

Köper

2019

Nano Convergence

View full text Add to dashboard Cite

Surface modified gold nanoparticles are becoming more and more popular for use in biomaterials due to the possibility for specific targeting and increased biocompatibility. This review provides a summary of the recent literature surrounding polyelectrolyte coatings on spherical gold nanoparticles and their potential biomedical applications. The synthesis and layer-by layer coating approach are briefly discussed together with common characterisation methods. The potential applications and recent developments in drug delivery, gene therapy, photothermal therapy and imaging are summarized as well as the effects on cellular uptake and toxicity. Finally, the future outlook for polyelectrolyte coated gold nanoparticles is explored, focusing on their use in biomedicine.

show abstract

Synthesis of curcumin-functionalized gold nanoparticles and cytotoxicity studies in human prostate cancer cell line

Cited by 48 publications

References 27 publications

Biodistribution and Physiologically-Based Pharmacokinetic Modeling of Gold Nanoparticles in Mice with Interspecies Extrapolation

Biodistribution and Physiologically-Based Pharmacokinetic Modeling of Gold Nanoparticles in Mice with Interspecies Extrapolation

Nanocurcumin: A Promising Candidate for Therapeutic Applications

Biomedical applications of polyelectrolyte coated spherical gold nanoparticles

Contact Info

Product

Resources

About