Synthesis of Cu(II), Ni(II), Co(II), and Mn(II) Complexes with Ciprofloxacin and Their Evaluation of Antimicrobial, Antioxidant and Anti-Tubercular Activity

Abstract

Co(II), Ni(II), Cu(II) and Mn(II) complexes synthesized by reflux of 6-bromo-3-(3-(4-chlorophenyl)acryloyl)-2Hchromen-2-one, Ciprofloxacin and various transition metal. 1 H, 13 C, IR and ESI Mass confirm the formation of ligand. The metal complexes were characterized on the basis of various spectroscopic techniques like IR studies and elemental analysis while the geometry of complexes was octahedral which is confirmed by electronic spectra and thermogravimetric analysis. The compounds were subjected to antimicrobial, antioxidant and anti-tubercular activity screening using serial broth dilution method and Minimum Inhibitory Concentration (MIC) is determined. Mn(II) complex has shown significant antifungal activity with an MIC of 6.25 µg/ml while Cu(II) complex is noticeable for antibacterial activity at the same concentration. Anti-TB activity of the ligand has enhanced on complexation with Ni(II) and Co(II) ions. While Ni(II) complex shows superior antioxidant activity than other complexes.

Synthesis, characterization and antimicrobial analysis of Schiff bases of o-phenylenediamine and 2-aminopyridine-3-carboxylic acid with ofloxacin and their metal (II) complexes

“…The IR spectra of the complexes displayed a discrete non ligand band with low intensity at 516-682 cm -1 for HL 1 -complexes and 578-663 cm -1 for HL 2 -complexes corresponding to ѵ(M-N) stretching vibrations. The band at 405-613 cm -1 for HL 1complexes and at 405-478 cm -1 for HL 2complexes is attributed to ѵ(M-O) stretching vibration mode which are similar to the reported works of Sultana et al (2013); Verma et al (2013); Patel et al (2012); and Imran et al (2007). These non-ligand spectral bands are indicators to the possible coordination of the azomethine nitrogen and the carboxylato oxygen to the metal ions (Sadeek et al, 2005).…”

Synthesis and characterization of azo dyes ligand complexes with some metal ions.

“…Azomethine group at 1640 cm -1 shifted to lower frequency of Zn(II) and Cd(II) complexes but no change of Sm(III) and Eu(III) complexes related to no coordination from this group (14) . (15) .The band at 1471 cm -1 related to azo group, this band shifted to lower frequency for all produced complexes (16) .The new bands for metal-nitrogen and metal-oxygen (17,18) at the range 430-5581 cm -1…”

Synthesis, Characterization and Microbial Evaluation of Heterocyclic Azo Dye Ligand Complexes of Some Transition Metal(II) Ions

“…Band at 1678 cm -1 is due to carbonyl ν(C=O) of acetyl group which has no significant change on complexation [28]. The band at 1657 cm -1 assigned to ν(C=O) vibration in the ligand, which on complexation has been disappeared due to lower frequency implied the coordination for metal(II) ions [29]. The band at 1512 cm -1 due to azo group is displaced into higher wavenumber for all the metal complexes [30].…”