Synthesis of Cross-linkable 2,5-Diketopiperazine Derivatives

Abstract

Synthesis of cross-linkable diketopiperadine derivatives is described. Cross-linkable a-amino acid methyl esters were subjected to peptide synthesis with Boc-protected glycine or L-tyrosine. No protections of cross-linkable functional groups (catechol and phenylazide) are necessary for constructions of diketopiperazine skeleton.