Synthesis of core-shell molecularly imprinted polymers (MIP) for spiramycin I and their application in MIP chromatography

Liu, Qi; Wan, Jiamin; Cao, Xuejun

doi:10.1016/j.procbio.2018.04.001

Cited by 29 publications

(12 citation statements)

References 28 publications

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“…MIPs are excellent materials with high selectivity and are widely used for sample preparation in bio analytical methods, as well as in sensors , chromatography , solid phase extraction , catalysis , and drug delivery and others.…”

Section: Introductioncontrasting

confidence: 62%

Recent Advances in Electrochemical Sensors Based on Molecularly Imprinted Polymers and Nanomaterials

2018

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This review focuses on the recent achievement during period of 2013–2018 related to the electrochemical sensors based on molecularly imprinted polymers (MIPs) combined with nanomaterials for various kinds of applications. MIPs based electrochemical sensors have found a great interest due to their high stability, short time required for electropolymerization, and high specificity towards the target analyte. The sensitivity is considered as one of the important parameter in electrochemical sensing strategies that should be improved by the combination of highly conductive nanomaterials with selective MIPs. In general, the most employed nanomaterials are magnetic nanoparticles, gold nanoparticles (AuNPs), carbon nanotubes and graphene. This review discusses the main current achievement as well as the current challenges regarding the development of biomimetic sensors in electroanalysis.

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Section: Introductioncontrasting

confidence: 62%

Recent Advances in Electrochemical Sensors Based on Molecularly Imprinted Polymers and Nanomaterials

2018

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“…27,28 At present time, there is a range of publications devoted to development and application of macroporous MIP monoliths in flow-through format for isolation and separation of various small molecules including drugs, pesticides, herbicides, amino acids, and so on. 12,29,30 Despite the successful application of MIP technique for the preparation of flow-through monoliths containing artificial recognition sites, there are still no works devoted to the development of such MIP monolithic layers for the application as microarrays. The use of thin MIP monolithic layers as 3D platforms for microanalysis can allow the selective identification of the marker of interest while the biochip cost will be reduced.…”

Section: Introductionmentioning

confidence: 99%

Molecularly imprinted macroporous polymer monolithic layers for L‐phenylalanine recognition in complex biological fluids

Antipchik

Dzhuzha

Sirotov

et al. 2020

J of Applied Polymer Sci

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In present work, the development of macroporous monolithic layers bearing the artificial recognition sites toward L‐phenylalanine has been carried out. The set of macroporous poly(2‐aminoethyl methacrylate‐co‐2‐hydroxyethyl methacrylate‐co‐ethylene glycol dimethacrylate) materials with average pore size ranged in 340–1200 nm was synthesized. The applicability of Hildebrand's and Hansen's theories for the prediction of polymer compatibility with porogenic solvents was evaluated. The dependences of average pore size on theoretically calculated parameters were plotted. The linear trend detected for Hansen's theory has indicated the high suitability of this approach to select appropriate porogens. The synthesized monolithic MIP layers were tested toward the ability to rebind phenylalanine‐derivative in microarray format. The influence of such factors as average pore size of the material, the concentration of template molecule in polymerization mixture, interaction time of analyte with its imprinted sites on binding efficiency were studied. The developed materials demonstrated good analyte rebinding from buffer solution with recognition factors 2.5–3.4 depending on the MIP sample. The comparable rebinding efficiency was also detected when the analysis was carried using complex biological media. The selectivity of phenylalanine binding from the equimolar mixture of structural analogues was 81.9% for free amino acid and 91.2% for labeled one.

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“…Many solid particles, like SiO 2 nanoparticles, [94][95][96][97] mesoporous SiO 2 , 98-100 chitosan, 101 metal-organic frameworks (MOFs), [102][103][104][105][106][107] PtPd nanoflowers, 108 TiO 2 , 109,110 polymers like PS 111 and PMMA, 112 fluorescent nanoparticles (FNPs), [113][114][115] Fe 3 O 4 magnetic nanoparticles (MNPs), etc., have been used as a supporting matrix. Silica nanoparticles are widely used to prepare core-shell structure MIPs because of their simple preparation and good stability.…”

Section: The Cores For Core-shell Mipsmentioning

confidence: 99%

Designing and controlling the morphology of spherical molecularly imprinted polymers

Tian

Wang

et al. 2020

Mater. Adv.

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Synthesis of core-shell molecularly imprinted polymers (MIP) for spiramycin I and their application in MIP chromatography

Cited by 29 publications

References 28 publications

Recent Advances in Electrochemical Sensors Based on Molecularly Imprinted Polymers and Nanomaterials

Recent Advances in Electrochemical Sensors Based on Molecularly Imprinted Polymers and Nanomaterials

Molecularly imprinted macroporous polymer monolithic layers for L‐phenylalanine recognition in complex biological fluids

Designing and controlling the morphology of spherical molecularly imprinted polymers

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