Synthesis of Core‐Crosslinked Nanoparticles with Controlled Cylindrical Shape and Narrowly‐Dispersed Size via Core‐Shell Brush Block Copolymer Templates

Cheng, Chong; Qi, Kai; Germack, David S.; Khoshdel, Ezat; Wooley, Karen L.

doi:10.1002/adma.200602986

Cited by 52 publications

(48 citation statements)

References 37 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Up to now, compared to the other templates, block copolymer is the most favorite template for fabrication of mesoporous silica hollow spheres because of its simple process, low cost and facile adsorption of silica [2,6,21,[26][27][28][29][30]. In this paper, triblock copolymer PEG-PPG-PEG which has similar chemical properties with poly(ethylene oxide)-poly(propylene oxide)-poly(ethylene oxide) (PEO-PPO-PEO) was used as template.…”

Section: Introductionmentioning

confidence: 99%

Fabrication of mesoporous silica hollow spheres using triblock copolymer PEG–PPG–PEG as template

Wang

Miao

et al. 2010

Journal of Non-Crystalline Solids

View full text Add to dashboard Cite

Section: Introductionmentioning

confidence: 99%

Fabrication of mesoporous silica hollow spheres using triblock copolymer PEG–PPG–PEG as template

Wang

Miao

et al. 2010

Journal of Non-Crystalline Solids

View full text Add to dashboard Cite

“…[15,18,19] For instance, Wooley and co-workers reported various forms of shell-crosslinked micelles. [20][21][22][23][24][25] Armes and co-workers reported core-crosslinked stimuli-sensitive micelles. [26] The groups of Kissel and Hennink separately reported photo-polymerized corecrosslinked biodegradable micelles for the delivery of anticancer drugs.…”

Section: Introductionmentioning

confidence: 99%

Reduction‐Sensitive Reversibly Crosslinked Biodegradable Micelles for Triggered Release of Doxorubicin

Meng

Cheng

et al. 2009

Macromolecular Bioscience

View full text Add to dashboard Cite

Reduction-responsive reversibly crosslinked biodegradable micelles were developed and applied for triggered release of doxorubicin (DOX). An amphiphilic block copolymer of poly(ethylene glycol) (PEG) and poly(epsilon-caprolactone) (PCL) that contains two lipoyl functional groups at their interface (PEG-L(2)-PCL) has been synthesized. (1)H NMR spectroscopy and gel permeation chromatography (GPC) measurements show that the PEG-L(2)-PCL block copolymer had a controlled composition (PEG 5 kDa and PCL 5.4 kDa) and a polydispersity index (PDI) of 1.36. PEG-L(2)-PCL formed micelles with sizes that ranged from 20 to 150 nm in aqueous solutions, wherein a critical micelle concentration (CMC) of 16 mg.L(-1) was determined. The micelles were readily crosslinked by adding 7.6 mol % of dithiothreitol (DTT) relative to the lipoyl groups. Notably, micelles after crosslinking demonstrated a markedly enhanced stability against dilution, physiological salt concentration, and organic solvent. In the presence of 10 x 10(-3) M DTT, however, micelles were subject to rapid de-crosslinking. In vitro release studies showed minimal release of DOX from crosslinked micelles at a concentration of 10 mg L(-1) (C < CMC, analogous to intravenous injection), wherein less than 15% of the DOX was released in 10 h. In contrast, rapid release of DOX was observed for DOX-loaded non-crosslinked micelles under otherwise the same conditions ( approximately 80% release in 0.5 h). In the presence of 10 x 10(-3) M DTT mimicking an intracellular reductive environment, sustained release of DOX from crosslinked micelles was achieved, in which 75% of the DOX was released in 9 h. These novel reduction-sensitive reversibly crosslinked biodegradable micelles are highly promising for targeted intracellular delivery of anticancer drugs.

show abstract

“…Although near monodisperse cylindrical nanostructures can be obtained in the form of unimolecular micelles from bottle brush BCPs [22][23][24] and dendronized polymers, 25,26 time-consuming synthetic procedures are associated with the synthesis of the building blocks. Polydisperse cylindrical micelles can also be prepared from the self-assembly of BCPs with amorphous core-forming blocks in block selective solvents.…”

Section: Introductionmentioning

confidence: 99%

Monodisperse Cylindrical Micelles and Block Comicelles of Controlled Length in Aqueous Media

et al. 2016

View full text Add to dashboard Cite

Cylindrical block copolymer micelles have shown considerable promise in various fields of biomedical research. However, unlike spherical micelles and vesicles, control over their dimensions in biologically-relevant solvents has posed a key challenge that potentially limits in depth studies and their optimisation for applications. Here, we report the preparation of cylindrical micelles of length in the wide range of 40 nm -1.10 µm in aqueous media with narrow length distributions (length polydispersities < 1.10). In our approach, an amphiphilic linear-brush block copolymer, with high potential for functionalization, was synthesized based on poly(ferrocenyldimethylsilane)-b-poly(allyl glycidyl ether) (PFS-b-PAGE) decorated with triethylene glycol (TEG), abbreviated as PFS-b-(PEO-g-TEG). PFS-b-(PEO-g-TEG) cylindrical micelles of controlled length with low polydispersities were prepared in N,N-dimethylformamide using small seed initiators via living crystallization-driven self-assembly. Successful dispersion of these micelles into aqueous media was achieved by dialysis against deionized water. Furthermore, B-A-B amphiphilic triblock comicelles with PFS-b-poly(2-vinylpyridine) (P2VP) as hydrophobic "B" blocks and hydrophilic PFS-b-(PEO-g-TEG) "A" segments were prepared and their hierarchical self-assembly in aqueous media studied. It was found that superstructures formed depend on the length of the hydrophobic blocks. Quaternization of P2VP was shown to cause the disassembly of the superstructures, resulting in the first examples of water-soluble cylindrical multi-block comicelles. We also demonstrate the ability of the triblock comicelles with quaternized terminal segments to complex DNA and, thus, to potentially function as gene vectors.

show abstract

Synthesis of Core‐Crosslinked Nanoparticles with Controlled Cylindrical Shape and Narrowly‐Dispersed Size via Core‐Shell Brush Block Copolymer Templates

Cited by 52 publications

References 37 publications

Fabrication of mesoporous silica hollow spheres using triblock copolymer PEG–PPG–PEG as template

Fabrication of mesoporous silica hollow spheres using triblock copolymer PEG–PPG–PEG as template

Reduction‐Sensitive Reversibly Crosslinked Biodegradable Micelles for Triggered Release of Doxorubicin

Monodisperse Cylindrical Micelles and Block Comicelles of Controlled Length in Aqueous Media

Contact Info

Product

Resources

About