Synthesis of Complex Au/Ag Nanorods by Controlled Overgrowth

Park, Kyoungweon; Vaia, Richard A.

doi:10.1002/adma.200800613

Cited by 76 publications

(85 citation statements)

References 33 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The Au-NRs were synthesized through a dual surfactant, wet-chemistry based process utilizing cetyltrimethlyammonium bromide (CTAB) and benzyldimethylammonium chloride (BDAC) as previously described [18]. Synthesis was carried out through the addition of gold seeds to an aqueous solution, after which gold ions were reduced on the seed surface to form nanorods.…”

Section: Au-nr Synthesis and Characterizationmentioning

confidence: 99%

Physiological Fluid Specific Agglomeration Patterns Diminish Gold Nanorod Photothermal Characteristics

Comfort¹,

Speltz²,

Stacy³

et al. 2013

ANP

View full text Add to dashboard Cite

Investigations into the use of gold nanorods (Au-NRs) for biological applications are growing exponentially due to their distinctive physicochemical properties, which make them advantageous over other nanomaterials. Au-NRs are particularly renowned for their plasmonic characteristics, which generate a robust photothermal response when stimulated with light at a wavelength matching their surface plasmon resonance. Numerous reports have explored this nanophotonic phenomenon for temperature driven therapies; however, to date there is a significant knowledge gap pertaining to the kinetic heating profile of Au-NRs within a controlled physiological setting. In the present study, the impact of environmental composition on Au-NR behavior and degree of laser actuated thermal production was assessed. Through acellular evaluation, we identified a loss of photothermal efficiency in biologically relevant fluids and linked this response to excessive particle aggregation and an altered Au-NR spectral profile. Furthermore, to evaluate the potential impact of solution composition on the efficacy of nano-based biological applications, the degree of targeted cellular destruction was ascertained in vitro and was found to be susceptible to fluid-dependent modifications. In summary, this study identified a diminution of Au-NR nanophotonic response in artificial physiological fluids that translated to a loss of application efficiency, pinpointing a critical concern that must be considered to advance in vivo, nano-based bio-applications.

show abstract

Section: Au-nr Synthesis and Characterizationmentioning

confidence: 99%

Physiological Fluid Specific Agglomeration Patterns Diminish Gold Nanorod Photothermal Characteristics

Comfort¹,

Speltz²,

Stacy³

et al. 2013

ANP

View full text Add to dashboard Cite

show abstract

“…18 As the wave front of the light passes, its oscillating electromagnetic field will cause the free electrons of the nanoparticle to undergo a collective coherent movement with respect to the positive metallic lattice. 18,[21][22][23][24] Thus, the electron density in the particle will be polarized to one surface and then the other in resonance with the light's frequency, leading to a standing oscillation. 15 This phenomenon is known as localized surface plasmon resonance (LSPR).…”

Section: Properties Of Gold Nanoparticlesmentioning

confidence: 99%

“…24 Briefly, after the pellet was dispersed in 3 mL of DI water or CTAB, 4 µL of 1M NaOH was added to the gold nanorod solution in order to adjust the pH. Then, 1 mL of the 0.001M HAuCl4 aqueous solution, 0.75 mL of the 0.004M AgNO3 aqueous solution and 25.38 µL of 0.0788M ascorbic acid were added into the solution in this order.…”

Section: Synthesis Of Ag/aunrsmentioning

confidence: 99%

“…21,23 The core-shell structure is obtained by forming AuNRs first using the seedmediated growth method proposed by Nikoobakht, and then depositing silver onto the surface of the nanorods. [24][25] The Au-Ag bimetallic material shares similar optical properties as those of AuNPs, thus demonstrating promise in cancer detection and treatment through temperature increase after radiation, which originates from the localized surface plasmon resonance (LSPR) effect. [26][27] Moreover, by modulating the aspect ratio of the core structure, or the AuNRs in this case, the LSPR band of the bimetallic nanorods can be tuned into the near infrared region (NIR region), allowing for potential use in various biomedical applications.…”

Section: Introductionmentioning

confidence: 99%

“…[26][27] Moreover, by modulating the aspect ratio of the core structure, or the AuNRs in this case, the LSPR band of the bimetallic nanorods can be tuned into the near infrared region (NIR region), allowing for potential use in various biomedical applications. 24 AuNPs have been investigated for use in cancer cell imaging and photothermal therapy in the NIR region. …”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Biomedical applications of gold and silver nanoparticles

Zhang¹

View full text Add to dashboard Cite

Noble nanoparticles have attracted a large amount of attention among researchers due to their brilliant colors, which results from their unique optical properties from the localized surface plasmon resonance (LSPR) effect. Among different kinds of noble nanoparticles, gold and silver nanoparticles have been studied the most because of their superior properties.The unique optical properties of gold nanoparticles (AuNPs) depend on many different factors, such as the size and shape of the nanoparticles. Besides unique optical properties, AuNPs can be easily modified and conjugated with different kinds of. With these properties, AuNPs have been investigated in various biomedical applications, including cancer imaging and photothermal therapy.Silver nanoparticles (AgNPs) have been widely investigated as a promising antimicrobial agent after recent advances in nanotechnology. However, AgNPs have been found to cause cytotoxicity to mammalian cells in a dose-dependent manner. Therefore, it is necessary to either reduce the amount of AgNPs needed or combine them with other antimicrobial agents in order to employ the super antimicrobial properties of AgNPs.In the current study, AuNRs were first synthesized, characterized and tested on healthy mammalian cells and tumor cells. Results showed that synthesized AuNRs were highly toxic towards tumor cells and at the same time had little or no influence on healthy human dermal fibroblasts at a certain concentration range.iii Next, silver-coated AuNRs (Ag/AuNRs) were synthesized in order to employ the antimicrobial properties of silver. Their antimicrobial properties were tested on different bacteria species. Furthermore, TEM images showed "pits" on the treated S. aureus membrane. Also, fluorescence assays of the bacteria species treated with Ag/AuNRs showed much less bacteria and no formation of biofilms. The cytotoxicity of the Ag/AuNRs was investigated and no obvious decrease in HDF proliferation was found up to a certain concentration.Finally, some other shapes of nanoparticles, gold nanospheres and gold nanostars, were synthesized and characterized. Results showed limited tunability of gold nanospheres in their absorption band. However, they have the potential to be used as drug delivery systems. In contrast, the absorption bands of gold nanostars can be tuned to the NIR region for applications involving imaging and photothermal therapy. First of all, I would like to thank my advisor, Dr. Thomas J. Webster, for his invaluable instruction, support and encouragement over the past four years. His knowledge and experience has prepared me for my future career more than I could have ever imagined.

show abstract