Synthesis of comb type and semi-interpenetrating networks of acryloyl-l-proline methyl ester and poly (acrylic acid) for Cu (II) immobilization

Gonzalez, Giovanni Villanueva; Burillo, Guillermina

doi:10.1016/j.radphyschem.2010.03.012

Cited by 6 publications

(1 citation statement)

References 16 publications

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“…1) The first is post-grafting polymerization from the network. Different groups utilized γ -radiation to generate polymeric radicals in the network and initiate grafting polymerization of vinyl monomers, resulting in the comb-type grafted hydrogels of the poly(acrylic acid) (PAA) network grafted with poly(4-vinylpiridine) [ 30 ], the PAA network grafted with PNIPAM [ 31 , 32 ] and the PAA network grafted with poly(acryloyl- l -prolinemethyl ester) [ 33 ]. However, those grafting polymerizations are badly controlled considering the grafting chain length.…”

Section: Introductionmentioning

confidence: 99%

Comb-Type Grafted Hydrogels of PNIPAM and PDMAEMA with Reversed Network-Graft Architectures from Controlled Radical Polymerizations

Chen¹,

Li²,

Pan³

et al. 2016

Polymers

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Dual thermo-and pH-responsive comb-type grafted hydrogels of poly(N,N-dimethy laminoethyl methacrylate) (PDMAEMA) and poly(N-isopropylacrylamide) (PNIPAM) with reversed network-graft architectures were synthesized by the combination of atom transfer radical polymerization (ATRP), reversible addition-fragmentation chain transfer (RAFT) polymerization and click chemistry.Two kinds of macro-cross-linkers with two azido groups at one chain-end and different chain length [PNIPAM-(N 3 ) 2 and PDMAEMA-(N 3 ) 2 ] were prepared with N,N-di(β-azidoethyl) 2-halocarboxylamide as the ATRP initiator. Through RAFT copolymerization of DMAEMA or NIPAM with propargyl acrylate (ProA) using dibenzyltrithiocarbonate as a chain transfer agent, two network precursors with different content of alkynyl side-groups [P(DMAEMA-co-ProA) and P(NIPAM-co-ProA)] were obtained. The subsequent azido-alkynyl click reaction of macro-cross-linkers and network precursors led to the formation of the network-graft hydrogels. These dual stimulus-sensitive hydrogels exhibited rapid response, high swelling ratio and reproducible swelling/de-swelling cycles under different temperatures and pH values. The influences of cross-linkage density and network-graft architecture on the properties of the hydrogels were investigated. The release of ceftriaxone sodium from these hydrogels showed both thermal-and pH-dependence, suggesting the feasibility of these hydrogels as thermo-and pH-dependent drug release devices.

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